Bleomycin-Induced Cryptogenic Organizing Pneumonia Manifested as Spontaneous Pneumothorax in a Patient with Classic Seminoma

Ortíz-Farías, Diana Lizbeth; López-Romero, Stephanie; Barrera-Pérez, Hirian Alonso Moshe; VargasMendoza, Gary Kosai; Cortes-Telles, Arturo

Bleomycin-Induced Cryptogenic Organizing Pneumonia Manifested as Spontaneous Pneumothorax in a Patient with Classic Seminoma

Authors

Diana Lizbeth Ortíz-Farías ¹

Stephanie López-Romero ¹

Hirian Alonso Moshe Barrera-Pérez ²

Gary Kosai VargasMendoza ³

Arturo Cortes-Telles ³

¹ Departamento de Neumología y Cirugía de Tórax. Hospital Regional de Alta Especialidad de la Península de Yucatán.

² Anatomía Patológica ANAPAT. Mérida, Yucatán, México

³ Departamento de Neumología y Cirugía de Tórax. Hospital Regional de Alta Especialidad de la Península de Yucatán.

Abstract

Cryptogenic Organizing Pneumonia (COP) can manifest like a collagen disorder or infectious diseases, or be caused by drug induced toxicity. This paper presents the case of a 24 year-old man diagnosed with classic seminoma, treated with chemotherapy scheme that included bleomycin (accumulated dose, 120 units). The patient was admitted at the hospital due to rapidly-progressing dyspnea and thoracic pain. The diagnostic approach revealed the presence of a spontaneous pneumothorax, while a lung biopsy documented COP. Despite treatment, the patient died from disease progression.

Keywords

Bleomycin

Cryptogenic Organizing Pneumonia

Pneumothorax

Toxicity