Comparison of Lymphocyte Number and Their Subsets in Patients with Diabetes Mellitus Type II, Tuberculosis and Concomitant TB and Diabetes

Authors

1 Department of Infectious Diseases,

2 Department of Pulmonary Medicine, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services,

3 Department of Endocrinology, Tehran University of Medical Sciences and Health Services,

4 Department of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN

Abstract

Background: Diabetics are prone to tuberculosis infection in part due to cellular immunity dysfunction, but the precise mechanism has not been fully understood yet. Materials and Methods: This study was performed in NRITLD between August 1999 and August 2001 to elucidate the quantitative status of cellular immunity. We measured the number of B lymphocytes, T lymphocytes, Natural Killer (NK) cells, and their sub-units in three groups of patients with diabetes mellitus (DM), pulmonary tuberculosis (TB) and pulmonary tuberculosis associated with DM (TB+ DM); and compared their results with age - matched healthy controls. Results: The number of these cells had not significant quantitative difference in TB and also DM patients comparing with healthy controls. A significant difference in total number of T lymphocytes and sub- units of helper T cell was observed in patients with concomitant TB and DM. Conclusion: These results indicate that patients with diabetes mellitus type II do not quantitatively develop cellular immunity dysfunction, a finding that may be seen in patients with concomitant TB and DM. (Tanaffos 2002; 1(4): 45-50)

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