Document Type : Original Article
Authors
1
Pulmonary Rehabilitation Research Center (PRRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2
Chronic Respiratory Diseases Research Center (CRDRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3
Physiotherapy Research Center, School of Rehabilita-tion, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4
Tobacco Prevention and Control Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5
Virology Research Center (VRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6
Lung Transplantation Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7
Social Determinants of Health Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical Sciences, Zanjan, Iran
8
Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University Zanjan, Iran
Abstract
Background: There are no definitive treatment options yet for Chronic Obstructive Pulmonary Disease (COPD). This study investigated the efficacy of Green Nature Deep Lung Support, a novel herbal formulation derived from plant-based ingredients, in improving clinical outcomes during COPD exacerbations.
Materials and Methods: The present double-blind, randomized clinical trial was conducted on patients with COPD exacerbation grade D who needed rehabilitation. The first group received a placebo, whereas the second and third groups received one and three capsules daily, respectively. Clinical symptoms and inflammatory biomarkers, including IL-6, IL-8, CBC, and CRP, were compared among the three groups.
Results: The use of Green Nature Deep Lung Support led to a significant decrease in the values of indicators such as Systolic Blood Pressure (SBP), Respiratory Rate (RR), Cr, IL-8, and ESR, and an increase in SpO2 after the intervention (P<0.05). Specifically, compared to pre-intervention values, SBP decreased from 131.25±13.76 to 126.25±8.41 (P<0.01). RR decreased from 17.10±1.21 to 16.00±0.65 (P<0.01), and SpO2 increased from 69.21±17.35 to 80.21±11.08 (P<0.001). No significant changes were observed in other indicators such as Diastolic Blood Pressure (DBP), pH, and pCO2 (P>0.05). Furthermore, IL-8 and CRP decreased from 28.65±34.55 to 15.81±20.16 (P<0.05) and from 19.18±13.44 to 9.38±10.98 (P<0.001), respectively.
Conclusion: Green Nature Deep Lung Support supplement may be associated with modest improvements in inflammatory indices in COPD patients. Larger multicenter trials are required to confirm these preliminary findings and optimize dosing.
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