Document Type : Original Article
Authors
1
Department of Anesthesiology and Operating Room, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2
Department of Anesthesiology and Pain Medicine, School of Medicine, Hasheminejad Kidney Center, Iran University of Medical Science, Tehran, Iran
3
Department of Laboratory Sciences, School of Paramedical Sciences Guilan University of Medical Sciences, Langeroud, Iran
4
Department of Anesthesia, School of Medicine and Hospital Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran
5
Department of Anesthesiology and Pain Medicine, School of Medicine, Hasheminejad Kidney Center, Iran University of Medical Science, Tehran, Iran
6
Department of Community Medicine, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Abstract
Background: The rise in coronary artery disease (CAD) due to increased life expectancy has made coronary artery bypass grafting (CABG) more common. However, CABG often leads to pulmonary dysfunction from cardiopulmonary bypass (CPB)-induced inflammation. This study evaluated the effect of intravenous ketamine during anesthesia induction on ICU extubation time.
Materials and Methods: This randomized controlled trial adhered to the CONSORT guidelines and included 60 patients scheduled for CABG at the Hazrat Rasoul Akram Research Center. Patients were randomly assigned to either a ketamine (0.5 mg/kg) or a placebo group. Extubation time and respiratory parameters (SpO₂, PaO₂, PaCO₂) were measured and analyzed using SPSS 19 with significance at p < 0.05.
Results: No significant differences were observed between the control and intervention groups regarding demographic or surgical characteristics (p>0.05). Most patients in both groups were extubated within 6 hours of ICU admission, with no significant difference in extubation times between groups. However, the SpO2 level was significantly higher in the ketamine group (P=0.046). No significant difference was found in PaCO2 levels (P=0.093), while PaO2 levels increased significantly in the ketamine group (P < 0.05).
Conclusion: This study assessed the effect of intravenous ketamine during anesthesia induction on extubation time in patients undergoing CABG. Results showed no significant impact on extubation timing, with most patients extubated within 6 hours. However, ketamine improved respiratory parameters (SpO₂ and PaO₂), suggesting potential benefits for postoperative respiratory function. Future research should explore its role in postoperative outcomes, dosing, combinations, and anti-inflammatory effects to fully assess its therapeutic value.
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