Document Type : Original Article
Authors
1
Pediatric Respiratory Diseases Research Center (PRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2
Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4
International Modern Hospital, Dubai, United Arab Emirates
Abstract
Background: This study aimed to determine the correlation between plasma Pro-BNP levels and MRI and echocardiographic findings in patients with repaired Tetralogy of Fallot (rTOF) undergoing surgical pulmonary valve replacement (PVR) to optimize valve implantation timing and reduce intervention costs.
Materials and Methods: Twenty-six patients who met the criteria for undergoing surgical pulmonary valve replacement at the tertiary medical center of Modarres Hospital from May 2019 to December 2023 enrolled in the study. We compared echocardiographic findings (LVEF, TAPSE, LVED diameter, Residual VSD, AI) and MRI data (right ventricular systolic and diastolic volume index, RV and LV ejection fraction) with Pro-BNP levels.
Results: This research studied 26 patients with a mean age of 16.5 ± 9.43 years. Plasma Pro-BNP levels ranged from 33.60 to 2095 pg/mL, with a mean ± SD of 212.15±395.22 pg/mL. Based on the results, there was no significant relationship between Pro-BNP level and RVESVI, LVEF, RVEF, TAPSE, RVEDVI, LVEDD, and Residual VSD. The results showed that there is a positive and significant correlation between Pro-BNP level and the age of the patients. According to the results of this study, there was a significant relationship between the incidence of aortic valve regurgitation (AR) and plasma Pro-BNP levels.
Conclusion: Regarding the results of the present study and the lack of a proven statistical relationship between the plasma Pro-BNP level and most of the findings of echocardiography and MRI, it can be concluded that serum Pro-BNP is not an acceptable measure to decide on PVR surgery, and MRI still determines the indication of PVR surgery.
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