Genetic Variants in Inflammatory Response Genes and Lung Cancer Risk: A Case-Control Study

Khosravi, Adnan; Seifi, Sharareh; Salimi, Babak D; Mabani, Maryam; Rostami, Patsa; Nomani, Masoumeh; Seif, Shima; Dezhkhi, Hoda; Sadatkiaei, Seyedeh Faezeh

Genetic Variants in Inflammatory Response Genes and Lung Cancer Risk: A Case-Control Study

Document Type : Original Article

Authors

Adnan Khosravi ¹

Sharareh Seifi ¹

Babak D Salimi ¹

Maryam Mabani ¹

Patsa Rostami ¹

Masoumeh Nomani ¹

Shima Seif ²

Hoda Dezhkhi ²

Seyedeh Faezeh Sadatkiaei ¹

¹ Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

² Mycobacteriology Research Center (MRS), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background: Lung cancer, a leading cause of cancer-related mortality, is influenced by both environmental and genetic factors. Chronic inflammation is recognized as a key driver of tumorigenesis. This study investigates the role of genetic variations in three inflammatory response genes in modulating lung cancer susceptibility. By examining the frequencies of specific polymorphisms in lung cancer patients and healthy controls, we aim to identify potential genetic markers for increased risk.
Materials and Methods: We conducted a case-control study comparing the frequencies of 5 inflammatory response gene polymorphisms (TNF-α-308, TNF-α-238, IFN-γ-2109, IL-10-819, and IL-10-1082) in 62 patients with lung cancer and 78 controls. DNA samples were genotyped using PCR-based methods, and statistical analyses were performed to assess the associations between polymorphisms and lung cancer risk.
Results: This study is the first to comprehensively analyze five key inflammatory response gene polymorphisms (TNF-α-308, TNF-α-238, IFN-γ-2109, IL-10-819, and IL-10-1082) in lung cancer patients. Our findings reveal significant associations between four of these polymorphisms and lung cancer risk.
Conclusion: This study provides novel insights into the genetic basis of lung cancer susceptibility, highlighting the potential role of inflammatory response gene polymorphisms as biomarkers for risk assessment. Future research should develop deeper into the underlying biological mechanisms through which these genetic variants influence lung cancer development. By elucidating these pathways, we may identify novel therapeutic targets and develop personalized prevention and treatment strategies.

Keywords

Lung cancer

Polymorphisms

Cancer Risk

Iran

Subjects