Background: This study describes the status of 548 smokers who participated in the monthly quitting course of the first “ Smoking Cessation Clinic” in Iran between the years 1998 through 2000. Materials and Methods: All the target population completed the educational courses, which consisted of 7 sessions of 90 minutes in the groups of 6-15. Cigarette intake per/day among the smokers was: in 92 cases (16.9%) less than 10 cigarettes, in 262(48.1%) between 11-20 cigarettes, and in the remaining 191(35%) more than 20 cigarettes. Results: The percentages of cessation in these three groups were 95.7%, 89.3%, and 83.8% respectively. This shows that the quitting rates among those who smoke less are significantly high (X2 for trend: p=0.003). Among them, 193(35.2%) attended all the visits regularly, 177(32.3%) were absent for one session and 178(32.5%) for 2-3 sessions. The quitting percentage in these groups were 94.8%, 93.8%, and 75.8% respectively, the relationship remains significantly associated with the lower absence rate (p=0.0001). There was no significant difference between the percentage of men and women who failed to complete the educational monthly course for any reasons (p=0.72). Besides, no significant difference was observed between both genders who had succeeded to quit (p=0.12). Conclusion: The results confirm that the cessation rate in those who have smoked less cigarettes and attended the clinic courses more regularly were significantly more successful than the others. (Tanaffos 2002; 1(4): 61-67)