The Effect of One Year INH Prophylaxis in Reduction of Clinical TB in HIV-Infected Injecting Drug User Males


1 HIV/STI Counseling and Care Center, Kermanshah University of Medical Sciences,

2 Department of Infectious Diseases, NRITLD, Shaheed Beheshti University of Medical Sciences, TEHRAN-IRAN


Background: Due to increased prevalence of tuberculosis among HIV-infected patients, INH (Isoniazid) chemoprophylaxis has a major impact on the development of clinical tuberculosis. Materials and Methods: For the evaluation of INH effect on prevention, we used INH, 300 mg daily for 115 available TST (tuberculin skin test) positive HIV-infected patients for twelve months. Results: During three-year follow up, only twelve patients developed tuberculosis which was significantly lower than minimum estimated rate among these patients (>10% per year). Conclusion: We conclude that INH prophylaxis was effective method to prevent clinical tuberculosis among TST positive HIV-infected patients. (Tanaffos 2003; 2(5): 57-61)