The Study of Diagnosed Venous Thromboembolism


Department of Internal Medicine, Pulmonary Division, Imam-Khomeini Hospital, Tehran University of Medical Sciences and Health Services, TEHRAN- IRAN


Background: Pulmonary Thromboembolism (PTE) is the most common preventable cause of death in European and North American hospitalized patients. There are some differences in Venous Thromboembolism (VTE) epidemiology among different populations. This study was performed to determine the hospital incidence and case fatality rate of VTE and its association with risk factors. Materials and Methods: Careful reviewing of records of all patients discharged during an 8-year period (1989-1997) with the diagnosis of Deep Vein Thrombosis (DVT) and/or PTE. Results: There were 70 patients with PTE and 140 with DVT. The hospital incidence of VTE was 9 per 10/000. The mean age was 41 and female/male ratio was 1.6. One or more risk factors for VTE were present in 95% of patients, two or more in 67%. The most common ones were age>40 years (45%), prolonged immobility (29%), pregnancy or puerperium (28%), major surgery (16%), and history of VTE (16%). No patient had received DVT prophylaxis. Case fatality rate of PTE was 11%. Conclusion: The hospital VTE incidence is much lower than Western counterparts. The most important reasons may be youthfulness of Iran population and probably their hematological profiles. As the populations mean age is increasing, VTE incidence may be much higher in the future. Our study confirms earlier reported risk factors. Because of high birth rate, pregnancy and puerperium are among the most important risk factors. Prophylaxis for VTE is highly underused by our physicians. Clinical features and mortality rate conform well to western reports. (Tanaffos 2003; 2(5): 15-22)