Background: Cigarette smoking is considered as the commonest preventable cause of morbidity and mortality. Materials and Methods: The present study shows that over a 2- year period, a total of 743smokers have been registered in monthly therapeutic and training courses of Smoking Cessation Clinic. They have received audio-visual training and behavioral therapy. For Nicotine Replacement Therapy (NRT), nicotine dependence of the patients was assessed by Fagrostrom Tolerance Test in the beginning of each course. Results: The test scores of 170 people (31.2%) were less than 7 (low nicotine dependence), and 376 individuals (68.8%) had scores of 7 or more (high nicotine dependence). At the end of the course, 90% from the first group and 87.5% from the second group had successfully quitted smoking. In the above-mentioned groups, 23.5% from the first group and 48.9% from the second one received not only behavioral therapy but also NRT. However, it is noteworthy that all the smokers with respect to the training provided during the course were prescribed NRT while its usage was up to the patient. This means that half of the second group (51.1%) had succeeded to quit smoking only by means of education and behavioral therapy without any NRT. Conclusion: The role of this kind of training in implementing smoking cessation program is essential. (Tanaffos 2003; 2(6): 39-44)