Microbiological Pattern and Risk Factors of Bacterial Colonization in Patients with Clinically Stable Boronchiectasis


1 Department of Internal Medicine

2 Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences and Health Services, SARI-IRAN.


Background: Bronchiectasis, dilatation of bronchi with diameter more than 2 mm is a septic and inflammatory process of the lung, caused by infections and systemic or local defense abnormalities of tracheobronchial tree that may lead to destruction of bronchial wall. Infections usually cause inflammatory reaction and destruction of bronchial wall, this further leads to more disturbance in local defense and a vicious cycle of inflammation and bacterial colonization occurs. These bacteria divided to Potentially Pathogen Microorganism (PPM) or non-PPM. The purpose of this study was to find microbiologic pattern and associated (risk) factors in Iranian population and use of more narrow spectrum antibiotics. Materials and Methods: Forty patients with proven diagnosis of bronchiectasis by HRCT in a clinically stable condition fulfilled the inclusion criteria. Fiberoptic bronchoscopy was performed just after spirometry and BAL sampling was achieved. Cut off point of 10000 CFU was considered for positivity of culture media. Results: S. pneumoniae was the predominant pathogen. There was 85% rate of colonization by PPM. We found FEV1< 80% and FVC< 80% as risk factors for bacterial colonization by PPM and S. pneumoniae. Age of diagnosis