TANAFFOS (Respiration)

TANAFFOS (Respiration)

Proline-Glycine-Proline as a Potential Biomarker in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis

Authors
Arne Lucas ten Hoeve 1
Mojtaba Abdul Roda 1
Frank Redegeld 1
Gert F olkerts 1
James Edwin Blalock 2
Amit Gaggar 2
1 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands
2 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Abstract
The present review discusses the role of tri-peptide Proline –Glycine -Proline (PGP) as a potential player, biomarker and therapeutic target in this process.
Keywords
Chemotactic factors
Cystic fibrosis
Chronic obstructive pulmonary disease
Extracellular matrix
Neutrophil activation praline
Interleukin-8 A and B
Serine ednopeptidases