Background: Exposure to secondhand cigarette smoke is an important health hazard. This study was designed to assess the sociodemographic risk factors related to women’s exposure to secondhand smoke. Materials and Methods: A case-control analysis of data collected as part of a prospective cohort study was conducted. Participants were 340 female Tehran residents exposed to cigarette smoke. Women consented to participate in this study and completed a questionnaire containing socio-demographic characteristics, household characteristics and smoking status at home through a face-to-face interview. Factors related to women’s exposure to secondhand smoke were assessed using the multivariate logistic regression model. Results: The final multivariate logistic regression model showed that lower levels of education (p=0.002) and social class (p=0.03) increase the risk of exposure to secondhand smoke in women. Conclusion: These results support the effect of women’s educational level and social class on their exposure to secondhand smoke.