Effect of Chamomile Hydroalcoholic Extract on BleomycinInduced Pulmonary Fibrosis in Rat


1 Department of Pharmacology, School of Pharmacy and Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

2 Department of Toxicology, School of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

3 Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran


Background: The aim of the present study was to investigate the effect of the Chamomile hydroalcoholic extract on bleomycin-induced pulmonary fibrosis in rat. Materials and Methods: Rats (N.Mari, 180-220 g) of either sex were given a single intratracheal instillation of bleomycin (7.5 IU/Kg) or the vehicle (saline). Treatment groups were given the same dose of bleomycin and then received different doses of oral chamomile hydroalcoholic extract (400, 600, 800, 1000, and 1500 mg/kg/day) for two weeks. Results: Histological and pharmacological experiments of bleomycin-treated animals showed that bleomycin could cause marked pulmonary fibrosis within two weeks. In addition, administration of Chamomile hydroalcoholic extract reduced such damages in lung tissue in a dose-dependent manner. Best results were obtained with 1500 /kg/day of Chamomile hydroalcoholic extract. Conclusion: From the results of current study, it can be concluded that Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues. Such effect of Chamomile can be attributed to the ingredients of this plant with anti-inflammatory and anti-oxidant properties.