National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Hekmat-Based Medicine Approach in Masih Daneshvari Referral Pulmonary Hospital322323728961ENAli AkbarVelayatiClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMohammadVarahramMycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0002-8033-1867ElhamGhazanchaeiResearch Department for Hospital Management and Health Policy in Respiratory Diseases, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-6048-3396Journal Article20230911https://www.tanaffosjournal.ir/article_728961_31b9347bd41fea69a3eb273628a71f0e.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001The History of Anesthesia and Anesthesiologists in Iran324333729023ENAlirezaSalimiChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Science, Tehran, Iran0000-0001-5787-4807MakanSadrVirology Research Center, NRITLD, Shahid Beheshti University of Medical Science, Tehran, Ira0000-0002-8781-8176BabakDaneshfardChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Science, Tehran, IranCanadian College of Integrative Medicine (CCIM), Montreal, Quebec, CanadaPersian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran0000-0001-6729-9113Journal Article20250908The evolution of anesthesia and anesthesiology represents a pivotal chapter in the history of medical science, significantly enhancing patient care and surgical outcomes. General anesthesia, defined as the deliberate induction of a temporary state of pain relief, muscle paralysis, memory impairment, and unconsciousness, has revolutionized medical procedures by inhibiting the normal functioning of the central nervous system. In Iran, the journey of anesthesiology began with early contributions from ancient scholars and practitioners, whose innovative techniques laid the groundwork for future advancements. The field witnessed significant progress in the mid-20th century, aligning with global developments in medical science. Initially focused on intraoperative care, anesthesiology in Iran expanded to encompass preoperative evaluations, postoperative assessments, and comprehensive patient monitoring, addressing complications related to surgery and anesthesia. In addition to analyzing the evolution of anesthesiology from solely surgical intervention to a broader field encompassing preoperative evaluation, postoperative care, and critical care management, this paper addresses the challenges and opportunities facing anesthesia and anesthesiology in Iran, including the need for wider access to safe and reliable services and the integration of advanced technologies.https://www.tanaffosjournal.ir/article_729023_2b46e3ed5a9cd4977a52588672576ef1.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Thymoquinone Targeting T Helper 2 Cytokines in Animal Models of Asthma: A Systematic Review334340728962ENHaniehTahermohammadiChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0001-7742-2154AliAbdolahiniaChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranPersian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran0000-0001-8162-4883Mohammad AliTahermohammadiDepartment of Radiology, Iran University of Medical Sciences, Tehran, Iran0009-0001-3863-6739Mohammad AliHojjati KermaniClinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0002-2364-3696BabakDaneshfardChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranPersian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, IranCanadian College of Integrative Medicine (CCIM), Montreal, Quebec, Canada,Mizaj Health Research Institute (MHRI), Tehran, Iran0000-0001-6729-9113Ali AkbarVelayatiMycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0001-9398-5838Journal Article20231230<strong>Background: </strong>Thymoquinone (TQ) is one of the active components of <em>Nigella sativa</em> L. It has therapeutic properties in allergic diseases, such as the antihistamine effect on the airways of patients with asthma and inhibition of inflammatory changes. This systematic review was conducted to investigate the effect of TQ on T helper 2 (Th2) cytokines, including IL-4, IL-5, and IL-13, in the treatment of animal models of asthma.
<strong>Materials and Methods: </strong>A comprehensive article search was conducted using Web of Science, Scopus, and PubMed to find articles published until 2022 regarding the efficacy of TQ in treating animal models of asthma. We found 399 articles in Scopus, 927 in Web of Science, and 790 in PubMed, from a total number of 2116 articles. After deleting duplicate articles, we read the remaining 1126 titles and abstracts. Finally, 37 articles were selected for full reading. After excluding papers without full text, duplicates, letters, case studies, and those whose topic did not meet the criteria of this study, 8 articles remained. In the manual search, we did not find any deviating articles from the systematic search.
<strong>Results: </strong>Our results showed that TQ had a significant effect on the reduction of Th2 cytokines, including IL-4, IL-5, and IL-13, in animal models of asthma.
<strong>Conclusion: </strong>Current evidence shows the anti-inflammatory effects of TQ on Th2 cytokines, but its association with the reduction of Th2 cytokines in animal models of asthma needs further studies.https://www.tanaffosjournal.ir/article_728962_59029c626570c8b66b556deadd2286a7.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Sonography Guided Evaluation of Hemodynamic Indices in Critically Ill Patients Suffering from AKI during CRRT341348728963ENMortezaForoumandiDepartment of Intensive Care Medicine, Tehran University of Medical Sciences, Tehran, Iran0000-0001-5921-700XSeyedpouzhiaShojaeiDepartment of Critical Care Medicine, Imam Hossein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0001-8708-0119BatoulKhoundabiIran Helal Institute of Applied-Science and Technology, Red Crescent Society of Iran, Tehran, Iran0000-0001-8558-4735FarinRashid FarokhiCKD Research Centre, Shahid Beheshti University of Medical Science, Tehran, IranTelemedicine Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Science, Tehran, IranMehrdadBakhshayesh KaramChronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0003-4864-6161AhsinaJahan LopaMBBS, FICM, ICU in-charge, Department of ICU and Emergency, Shahabuddin Medical College Hospital, Dhaka, Bangladesh0000-0002-5336-4217HassanSafdariDepartment of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, Massachusetts, USA0000-0002-8209-0091RanajitChatterjeeMBBS, MRCP, FRCP, EDIC, DA(Gold Medal) FIACM Head Critical Care, Head Accident and Emergency Swami Dayanand Hospital, New Delhi, India0000-0003-2776-7802Seyed MohammadRezaHashemianChronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0002-0768-9168Journal Article20211119<strong>Background: </strong>Recent pieces of evidence have shown higher efficacy of continuous renal replacement therapy (CRRT) with regard to improvement of survival in critically ill patients by maintaining hemodynamic stability. The present study aimed to assess hemodynamic conditions before and after CRRT with the point-of-care approach.
<strong>Materials and Methods: </strong>The present interventional before-after study was performed on 20 critically ill patients with unstable hemodynamic status admitted to the ICU at Masih-e-Daneshvari Hospital in Tehran in 2019. They were candidate for CRRT due to acute kidney injury (AKI). The main pointed parameters for assessment before and after CRRT included heart rate, mean arterial pressure (MAP), central vein pressure (CVP), the carotid corrected flow time (FTc), carotid peak systolic velocity (PSV), inferior vena cava collapsibility (cIVC), resistive index (RI), and inferior vena cava (IVC) size and distensibility aided by ultrasonography.
<strong>Results: </strong>Regarding the changes in ultrasonography parameters after CRRT, except for carotid PSV, heart rate, and carotid area, other parameters showed a significant change. In this regard, IVC size, FTc, MAP, CVP, internal jugular vein (IJV) area, and RI all significantly decreased while IVC distensibility index significantly increased following CRRT. Similar changes were revealed in the subgroup of patients with hypotension, but in another subgroup without hypotension, the decrease in carotid PSV was also meaningful.
<strong>Conclusion: </strong>Applying CRRT in AKI patients in critically ill situations can effectively balance cardiovascular and hemodynamic parameters and thus lead to more appropriate survival. https://www.tanaffosjournal.ir/article_728963_677f5bf57156c8e608a93fd849e3cbe9.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Assessment of Clinical, Histopathologic, and Radiologic Features in Extrapulmonary Tuberculosis Patients349354728966ENLadanKharrazInfectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0002-5156-9905AidaBagheriInfectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranFirouzeHatamiInfectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0003-0450-0961Mohammad MahdiRabieiInfectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0001-9544-2861FaridJavandoust GharehbaghInfectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0001-9127-9470IladAlavi DarazamInfectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0002-4440-335XJournal Article20230910<strong>Background: </strong>Tuberculosis (TB) is clinically divided into two categories: pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB). PTB has many different manifestations, and sometimes the initial diagnosis is challenging and depends on the prevalence of infection as well as the experience and development of local medical centers. Thus, we aimed to review all EPTB patients in our referral center.
<strong>Materials and Methods: </strong>This retrospective study reviewed all confirmed cases of EPTB referred to a referral/general center within the last decade.
<strong>Results: </strong>This study included<strong> </strong>68 cases of EPTB. Percentages of males and females were 58.8% and 41.2%, respectively.<strong> </strong>The majority of EPTB patients were TB meningitis (44.1%), followed by musculoskeletal TB (17.6%).<strong> </strong>About 8.8% of patients had a positive culture. The acid-fast bacilli test was found to be positive in 19.1% of cases. The mortality rate in this study was 19.1% and the highest rate of mortality was observed in intestinal and mesenteric TB (33.3%).
<strong>Conclusion: </strong>According to this study, the majority of hospitalized EPTB patients had TB meningitis. The mortality rate in intestinal and mesenteric TB was higher compared to other types of EPTB, probably due to delayed diagnosis. In the current study, Positive results for smears and cultures were also low.https://www.tanaffosjournal.ir/article_728966_151d85905684370a29afafd4b03fb204.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Optimized Conservative Surgical Treatment of Pulmonary Hydatid Cyst: A Retrospective Observational Cohort Study355363728969ENAbdoulhosseinDavoodabadiDepartment of General and Thoracic Surgery, Kashan University of Medical Sciences, Kashan, IranFatemehNajjarianDepartments of General Surgery, Trauma Research Center, Kashan University of Medical Sciences, Kashan, IranMohammad JavaAzadchehrDepartment of Biostatistics and Epidemiology, Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, IranEsmailAbdorrahhmkashiDepartment of General and Thoracic Surgery, Kashan University of Medical Sciences, Kashan, IranHassanDavoodabadiDepartments of Surgery, Qom University of Medical Sciences, Qom, IranAboulhassanAlijanpourDepartments of Surgery, Babol University of Medical Sciences, SariBabakHaghpanahDepartments of Surgery, Kashan University of Medical Sciences, Kashan, IranJournal Article20220630<strong>Background: </strong>There are some controversies on surgical options for pulmonary hydatid cysts. We analyzed our experience in lung tissue preservation during the surgical treatment and optimal surgical options.
<strong>Materials and Methods: </strong>This observational cohort analysis was conducted from July 2008 to July 2022. The Age, sex, clinical manifestation, recurrent rate, hospital length of stay, postoperative complications, and long-term results in each group were assessed. The American Society of Anesthesiologists Physical Status, Charlson Co-Morbidity Index (CCI), Complexity of surgery, and Clavien-Dindo score were also determined.
<strong>Results: </strong>Out of 138 patients, 81case (53.5%) had intact cysts (G1), and the rest were infected cysts which in turn were subdivided into early infected (G2) and cavity suppurated=28 cases (18.4%) as (G3). Group G3 required special attention because the pericyst surface was severely inflamed, dirty, and had pus, so they were subdivided into 3 distinctive groups including G3a, undergone cystectomy, bronchial opening closure alone, G3b group, undergone cystectomy, capitonnage+bronchial opening closure and G3c group, in which pericystectomy also added to previously mentioned procedures. Major complications in the subgroups of G3a were 2 patients and G3b 3 patients, but in the subgroup of G3c, no considerable complications were seen.
Cystectomy, closure of major bronchial opening, and capitonnage were done in intact, and early infected cysts. The results of both were the same, with no considerable major complication.
<strong>Conclusion: </strong>Capitonnage significantly decreased the complication rate. The optimized approach in both G1 and G2 was: cystectomy, closure of major bronchial opening, and capitonnage. In G3, bronchial opening closure, pericystectomy, and capitonnage were the preferred procedures.https://www.tanaffosjournal.ir/article_728969_5f349cd8be9f05201c5d863358e71c90.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Clinical Symptoms and Echocardiographic Markers Regarding the Severity of Embolism in Patients with Acute Pulmonary Embolism364370728970ENShahabaddinSorouriLung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran0000-0002-4847-557XMaryamNaseriDepartment of Pediatrics, Mashhad University of Medical Sciences, Mashhad, IranSepidehHejaziLung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranJournal Article20231019<strong>Background: </strong>Echocardiography can be used for risk stratification in patients with acute pulmonary embolism (PE). While the severity of PE has been assessed through laboratory criteria in most studies, the Pulmonary Embolism Severity Index (PESI) scoring system was used in this study to evaluate the severity of echocardiographic criteria in acute PE patients.
<strong>Materials and Methods: </strong>All PE patients admitted to Ghaem Hospital in Mashhad between 2021-2022 were included in the study. Clinical symptoms and echocardiographic markers were checked and recorded when the patients entered the study. Data were analyzed in SPSS version 24 at a significance level of 0.05 using the Chi-square test and t-test.
<strong>Results: </strong>Of 40 patients, 80% were at a high risk of PESI. The most common clinical symptoms were dyspnea (97.5%) and pleuritic chest pain (75%). Right ventricle (RV) size enlargement and its dysfunction were recorded in 57.5% of patients. The average age of patients in the high-risk group was significantly (p-value: 0.001) higher than the low-risk group. There was a significant correlation between MID-right ventricle and pulmonary artery pressure with the severity of embolism, so that mid-right ventricle and pulmonary artery pressure in the high-risk group were significantly higher (p-value: 0.000) than in the low-risk group. Also, the severity of PE was significantly related to RV size (P = 0.026) and function (P = 0.038).
<strong>Conclusion: </strong>RV size, function, and dilatation, and pulmonary artery pressure variated significantly in different severities of PE.https://www.tanaffosjournal.ir/article_728970_ea5811d315aeccc31a0b95a544c29d7e.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Heart Rate Variability in Obstructive Sleep Apnea: Association with Excessive Daytime Sleepiness and Cardiovascular Risk371375728971ENBesharatRahimiThoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran0000-0003-0193-3243NiloofarKhoshnam RadThoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran0000-0001-6700-3570TayebeMohammad AlizadeThoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran0009-0004-3534-3887SomayeMohammadiDepartment of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran0009-0001-2045-5948ShahramFiroozbakhshThoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran0009-0008-3108-5795Journal Article20231029<strong>Background: </strong>Obstructive sleep apnea (OSA) is associated with increased vagal activity, sympathetic nervous system activation, and cardiovascular complications. Excessive daytime sleepiness (EDS) in OSA patients is a predictor of cardiovascular and all-cause mortality. Heart rate variability (HRV) can be used to assess cardiac autonomic modulation, which is affected by OSA. This study aimed to evaluate the relationship between HRV and daily sleepiness in OSA patients based on the excessive sleep scale (ESS) scores.
<strong>Materials and Methods: </strong>The study included 70 patients with OSA, divided into two groups: those with EDS (ESS ≥ 11) and those without sleepiness (ESS < 11). Time and frequency domain parameters were evaluated. The results were compared and analyzed between the two groups.
<strong>Results: </strong>Patients with OSA and EDS had higher cardiovascular risk, as indicated by different HRV parameters (higher low-frequency parameter and higher time domain parameters), compared to non-sleepy OSA patients. A significant positive correlation was found between ODI and AHI with VLF, and significantly higher LF and VLF in EDS patients.
<strong>Conclusion: </strong>OSA patients with EDS had higher cardiovascular risk, as indicated by different HRV parameters, compared to non-sleepy OSA patients. A significant positive correlation was found between ODI and AHI with VLF, and significantly higher LF and VLF in EDS patients. Further studies are needed to better understand the relationship between HRV and daily sleepiness in patients with OSA.https://www.tanaffosjournal.ir/article_728971_c157948f529ff2def21d6fdd72e479dd.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Predictors of Quality of Life in Patients with Asthma in Ahvaz, Iran376391728973ENAhmadTahmasebi GhorrabiSchool of Health Management & Information Sciences, Iran University of Medical Sciences, Tehran, IranSchool of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-0115-3688HaniehRajiDepartment of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0003-0495-0807AminTorabipourNursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Healthcare Services Management, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-8937-8004Seydeh MaryamMousaviSchool of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranZaharaOramanSchool of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0009-0005-5821-820xParisaBadiei NasabSchool of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0009-0006-0605-7552Mohammad HoseinHaghighizadehDepartment of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-4197-0199Journal Article20231114<strong>Background: </strong>Asthma impacts the quality of life (QOL) of patients and their families. The magnitude of this morbidity is influenced by several factors, including age, disease duration, and others. This study was conducted to determine the predictors of quality of life in patients with asthma in Ahvaz, Iran.
<strong>Materials and Methods: </strong>This cross-sectional study was conducted among patients referred to the pulmonary clinics of Imam Khomeini and Golestan hospitals in Ahvaz in 2022. The quality of life was assessed using the SF-36v2 questionnaire. The effect of socio-demographic characteristics on quality-of-life scores was examined by t-test, one-way variance (ANOVA), Pearson's correlation coefficient, and regression models.
<strong>Results: </strong>From a total of 204 studied asthmatic patients, the average age of patients was 43.22±15.17 years. The average QOL in patients was 57.69±22.97. Physical role and social functioning had the lowest and highest mean scores among SF-36 dimensions, respectively. A significant difference was observed between the average QOL score and the variables of age, gender, education level, employment status, illness costs, illness severity, daily exercise, and number of visits (P<0.05). Most clinical, socio-demographic, and economic variables were predictors of SF-36, PCS, MCS, and QOL dimensions (P<0.05).
<strong>Conclusion: </strong>This study showed that the quality of life in asthmatic patients is affected by the severity of the disease, number of visits, age, sex, and education. By performing appropriate interventions on social and economic factors, the quality of life of asthmatic patients can be improved.https://www.tanaffosjournal.ir/article_728973_414a3fdd93758c322085227f8e9b778c.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Effect of Chest Physiotherapy on the Clinical Outcomes of COVID-19 Patients392402728974ENRezaMoradi-AzhgilDepartment of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranNedaSayadiDepartment of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-8537-3185ShayestehHaghighiDepartment of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0003-2860-6410ParyaMoradiAhvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0009-0002-8835-4729Journal Article20231129<strong>Background: </strong>The novel coronavirus 2019 primarily affects the respiratory system and may lead to respiratory failure and the need for intubation. This study aimed to investigate the effect of chest physiotherapy on the clinical outcomes of patients with COVID-19.
<strong>Materials and Methods: </strong>This randomized clinical trial was performed in 2022-2023. The research population included 58 patients with COVID-19 who were hospitalized at Izeh Shohada Hospital, Khuzestan. Patients in the control group received routine care, which included the use of supportive drugs based on the doctor's opinion, oxygen therapy, and nutritional support. The intervention group received chest physiotherapy and breathing exercises for six days. At the end of the third and sixth days, the patients of both groups were evaluated in terms of lung function, respiratory gases, and the length of hospital stay. Moreover, the need for intubation was recorded during study time. Data analysis was done using SPSS version 23 software.
<strong>Results: </strong>In the intervention group, a significant improvement was observed in FVC (P<0.01), FEV<sub>1</sub>(P<0.01), FEV<sub>1</sub>/FVC ratio (P<0.01), PaO<sub>2 </sub>(P<0.01), PaCO<sub>2 </sub>(P<0.01), and SPO<sub>2</sub> (P<0.01) as well as the length of hospital stay (P<0.01) after the intervention. However, no significant difference was observed in the PaO2/FiO<sub>2 </sub>ratio (P>0.05) and the need for intubation (P>0.05).
<strong>Conclusion: </strong>The results showed that in the new crisis resulting from COVID-19, chest physiotherapy and respiratory exercises could be used as a helpful method in improving lung function, respiratory gases, and reducing the hospital stay in COVID-19 patients.https://www.tanaffosjournal.ir/article_728974_6ed4f73374f82d04db1ce68fab40eecd.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Effectiveness of Cognitive Behavioral Therapy and Motivational Interviewing on Perceived Stress and ICU Stay in Neurosurgical Patients: A Quasi-Experimental Study403408728975ENَAliSolgiPhD Student of Health Psychology, Department of Psychology, Emirate Branch, Islamic Azad University, Dubai, UAE0000-0001-8577-2306AlirezaZaliDepartment of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0002-2298-2290HassanAhadiDepartment of Psychology, Allameh Tabataba'i University, Tehran, IranFarhadJomehriDepartment of Psychology, Allameh Tabataba'i University, Tehran, IranJournal Article20231230<strong>Background: </strong>Neurosurgical operations, especially for brain tumors, are among the most stressful medical procedures due to diagnostic uncertainties, high morbidity, and long post-operative recovery, including ICU admission. Stress management interventions may improve outcomes. This study aimed to compare the effectiveness of Cognitive Behavioral Therapy (CBT) and Motivational Interviewing (MI) in reducing perceived pre- and post-operative stress and ICU stay in patients undergoing brain surgery.
<strong>Materials and Methods: </strong>In a quasi-experimental design, 80 neurosurgical candidates admitted to Shohadaye Tajrish Hospital during 2020–2022 were randomly assigned to intervention and control groups. The intervention group received 15 CBT-based sessions focused on stress management and cognitive restructuring. Stress levels were assessed using Cohen’s Perceived Stress Scale (1983), and CBT protocols followed Miller (2003). Data were analyzed with SPSS using chi-square tests, independent and paired t-tests, and ANCOVA.
<strong>Results: </strong>Patients who received CBT demonstrated significantly lower perceived stress scores postoperatively (p<0.001) and had a shorter ICU stay by an average of 3.2 days (p=0.049). No significant demographic differences were observed between groups.
<strong>Conclusion: </strong>CBT significantly reduces perioperative stress and ICU duration in neurosurgical patients. Integrating psychological interventions like CBT into preoperative care protocols may enhance recovery, reduce complications, and lower healthcare costs.https://www.tanaffosjournal.ir/article_728975_7608a573ddb547a48d79a04651e0a8f9.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Methylprednisolone-Induced Hyperlactatemia: A Case Report409412728976ENSarahSaenzDepartment of Anesthesiology, University of Wisconsin Hospital and Clinics, Madison, WI, USA0009-0009-8479-4373AnilaBhattiDepartment of Anesthesiology, University of Wisconsin Hospital and Clinics, Madison, WI, USA0009-0008-5471-6123AaronBeckDepartment of Orthopedic Surgery, University of Wisconsin Hospital and Clinics, Madison, WI, USA0000-0002-4847-6900Micah T.LongDepartment of Anesthesiology, University of Wisconsin Hospital and Clinics, Madison, WI, USA0000-0002-7297-5304Journal Article20230723Lactic acidosis is commonly encountered in critical care and can be a harbinger of life-threatening conditions and end-organ ischemia. Importantly, however, other etiologies of lactic acidosis exist. We review the first case of methylprednisolone-induced lactic acidosis in a previously healthy patient who suffered from traumatic spinal cord injury (SCI). A 19-year-old female presented to a level 1 trauma center after a fall resulted in lower extremity paralysis. After imaging revealed a chance fracture dislocation of T7-8 along with spinal cord compromise and swelling, the patient underwent emergent T5-T11 instrumented fusion. Postoperatively, she was given high-dose methylprednisolone in hopes of improving neurologic outcome; soon after administration, she developed lactic acidosis. After workup ruled out hypoperfusion and type A lactic acidosis, we determined that methylprednisolone likely induced non-ischemic, type B, lactic acidosis. The lactate quickly returned to baseline after steroid discontinuation. It is important for clinicians to consider type B lactic acidosis in the ICU in patients with persistent lactic acidosis after tissue hypoperfusion has been ruled out.https://www.tanaffosjournal.ir/article_728976_d87bce0e6d18c90bedcbdd275258bf3c.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001A Case of Pneumothorax Following Radiation Therapy for Small Cell Lung Cancer in a Patient with Scleroderma-ILD413416728977ENFatihUzerDepartment of Respiratory Diseases, Akdeniz University, Antalya, Türkiye0000-0001-9318-0458AykutCilliDepartment of Respiratory Diseases, Akdeniz University, Antalya, Türkiye0000-0001-9985-3502Journal Article20240302Connective tissue diseases, particularly scleroderma, pose a heightened risk for the development of malignancies such as breast and lung cancer. Stereotactic Body Radiation Therapy (SBRT) has emerged as an effective treatment modality for various cancers, including lung and breast cancers, due to its curative potential, especially for localized extracranial tumors. A 69-year-old patient with a 30-pack-year smoking history presented with shortness of breath and bilateral diffuse rales on chest auscultation during the outpatient clinic visit. Notably, the patient had not received scleroderma treatment for a year at the time of radiation therapy. Despite the recognized sensitivity of the lungs to radiotherapy, the occurrence of pneumothorax and pneumomediastinum following SBRT in this case raises concerns about the potential complications in scleroderma-ILD patients with lung cancer.
This report underscores the need for comprehensive risk assessment and careful consideration of alternative treatment strategies for lung cancer in scleroderma patients, particularly those with pre-existing lung involvement. Further research is warranted to elucidate the mechanisms and risk factors associated with complications following radiotherapy in this patient population, guiding clinicians in optimizing therapeutic approaches for improved outcomes.https://www.tanaffosjournal.ir/article_728977_c92680713c37470de3c3aaf91911dfa1.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001Hodgkin’s Lymphoma in a 34-Year-Old Patient with Digital Clubbing: A Case Report417420728979ENPouyanEbrahimiStudent Research Committee, Babol University of Medical Sciences, Babol, Iran0000-0003-2654-2169JalalHeshmatniaChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0003-2966-4380AmirmortezaSolemanijonianiDepartment of Internal Medicine, School of Medicine, Arak University of Medical Sciences, Arak, IranClinical Research Development Unit, Amiralmomenin Hospital, Arak University of Medical Sciences, Arak, Iran0000-0003-0236-8258Journal Article20230125<strong>Background: </strong>This is a rare condition, especially in adults, where digital clubbing presents as the initial manifestation of lymphoma. Here, we report a case of intrathoracic Hodgkin's disease (HD) with digital clubbing.
<strong>Case presentation:</strong> A 34-year-old female presented with B symptoms and a history of dyspnea. She did not take any particular medicine and had no history of any specific disease in herself or her family. In the examination, the patient has digital clubbing in the fingers and toes, which is painless. He also had decreased respiratory sounds and dullness in the right lung. After a CT scan and observation of consolidation and effusion, we performed a bronchoscopy on the patient. Finally, with the diagnosis of Hodgkin's lymphoma in the pathological reports, he was subjected to appropriate treatment measures.
<strong>Conclusion: </strong>A precise examination and paraclinical assistance are needed to rule out intrathoracic malignancies in patients with digital clubbing.https://www.tanaffosjournal.ir/article_728979_b5276de556e738e3291bed4491724612.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034423420241001A 15-Year-Old Girl with Chronic Cough and a History of Asthma Treatment421422728980ENMaryamHassanzadPediatric Respiratory Diseases Research Center (PRDRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran0000-0001-7164-0599KoroshFakhimi DerakhshanPediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran0000-0001-8294-9399Ali AkbarVelayatiMycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranJournal Article20230712A 15-year-old girl with wet coughing, occasional fever, nausea, and weight loss came to Masih Daneshvari Hospital. The patient has had dry coughing and wheezing in the last 2 years and was treated for asthma with short-acting beta-2 agonist and inhaler corticosteroids; however, coughs have not been treated completely. Moreover, overnight sweating, loss of appetite, and 10 kg weight loss have been added to the patient's symptoms since the previous year. On the admission day, the patient had a temperature of 38.2˚c, blood pressure of 95/65 mmHg, heart rate of 110 b/s, respiratory rate of 28, and O<sub>2</sub> saturation of 94% at room temperature. In the lung’s auscultation, the respiratory sound was decreased on the right side and normal on the left side. The results of the patient's laboratory tests were as follows: WBC: 13200 (neutrophils: 79%, lymphocytes: 12%), Hemoglobin: 4.7, ESR: 76, ACE: 21, IgG: 13, IgA: 4, IgM: 1, IgE: 500, and Anti-HIV antibody: non-reactive; besides, the liver tests were normal. Radiology and CT scans are shown in the following (Figure 1 A,B).https://www.tanaffosjournal.ir/article_728980_0c3c4f746f7c3a5562820d17971f7880.pdf