National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101The Value of Percutaneous Core Needle Biopsy in the Diagnosis of Anterior Mediastinal Tumors711241509ENEnayat SafaviDepartment of Internal Medicine, Pulmonary Division, Imam Khomeini Hospital, Tehran University of Medical Sciences and Health
Services, TEHRAN-IRAN.Seyed Majid HosseinianDepartment of Internal Medicine, Pulmonary Division, Imam Khomeini Hospital, Tehran University of Medical Sciences and Health
Services, TEHRAN-IRAN.Shahram FiroozbakhshDepartment of Internal Medicine, Pulmonary Division, Imam Khomeini Hospital, Tehran University of Medical Sciences and Health
Services, TEHRAN-IRAN.Journal Article20210106Background: Tissue diagnosis of anterior mediastinal tumors is very important for making correct therapeutic decision. To evaluate the value of performing percutaneous core needle biopsy in these tumors, we decided to perform this study. Materials and Methods: CT guided core needle biopsy was performed in 17 patients with anterior mediastinal tumor during an18-month period. The biopsy specimens were sent for histopathological study, and if the result was not definite, immunohistochemical studies were performed. Results: Percutaneous core needle biopsy provided adequate material in 15 from 17 cases. Of these 17 patients, 15 were diagnosed correctly by percutaneous core needle biopsy whereas 2 were not diagnosed definitely (one was “ spindle cell tumor” and another one was “suggestive for lymphoma”). The procedure was technically successful in 15 cases, and no complications occurred. Conclusion: CT-guided core needle biopsy of the anterior mediastinal tumors may be a safe, cost-effective and reliable method which can provide a precise diagnosis in the majority of mediastinal tumors and may obviate the need for anterior mediastinotomy or exploratory thoracotomy in cases which are medically treatable or non-resectable. (Tanaffos 2004; 3(9): 7-11)https://www.tanaffosjournal.ir/article_241509_e866c85ee655a65e4cd4751a16e3ed07.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Comparison of the Osteoporosis between Male Smokers with and without Chronic Obstructive Pulmonary Disease1318241510ENRoozbeh NaghshinDepartment of Pulmonary MedicineAli JavadzadehDepartment of Rheumatology, Hazrate Rasool-e-Akram Hospital, Iran University of Medical
Sciences and Health ServicesSeyed Ali Javad MousaviDepartment of Pulmonary MedicineSeyed Hassan AdeliDepartment of Pulmonary MedicineAkram HeydariCommunity Medicine unit, Qom University of Medical Sciences and Health Services, TERHAN-IRANJournal Article20210106Background: Osteoporosis is the most common metabolic bone disease that represents an increasingly serious problem, particularly as the population ages. It occurs because loss of bone mineral content. Osteoporosis, thus, causes significant morbidity, especially in elderly, due to recurrent pathologic fractures. It has been suggested that Chronic Obstructive Pulmonary Disease (COPD) is a risk factor for osteoporosis. We intended to investigate the relationship between COPD and osteoporosis in our patient population. Materials and Methods: Setting: Pulmonary diseases division of Hazrate Rasool-e-Akram hospital. Design: It is a case- control study. Target: One hundred volunteer men with history of at least 20 pack year cigarette smoking were sequentially assigned into two groups: 50 patients with COPD (according to the result of spirometry) and a control group of 50 individuals of matching age. Interventions: All individuals were underwent Bone Mass Densitometry (BMD) by Dual-Energy X-Ray Absorptiometry (DEXA), and Pulmonary Function Testing (PFT). Statistical Analysis: The data was processed using descriptive statistical analysis and t-test and χ 2 test. Results: The frequency of osteoporosis in our patient and control groups were 52% (26 patients) and 8% (4 persons), respectively. The mean T-score value of spinal bone density in patient and control groups were -1.15 and +0.62 respectively (p <0.0001). The mean T-score value of femoral bone density was -2.58 in patient group and -0.49 in controls (p <0.0001). There was a statistically significant correlation between the presence of osteoporosis with both the severity and duration of COPD (p <0.0001). However, BMD was not correlated with the body mass index (BMI), age or the amount of cigarette smoking. Patients with COPD are 12.5 times more likely than their controls to develop osteoporosis (OR: 12.46, CI 95% = 3.9 – 39.85). Conclusion: Our study confirms that COPD is a risk factor for osteoporosis. There may be many contributing factors such as immobility, chronic respiratory acidosis and the use of gluccocorticoids. Therefore, prevention of osteoporosis should be a part of medical care for COPD patients. (Tanaffos 2004; 3(9): 13-18)https://www.tanaffosjournal.ir/article_241510_638cf878c9d4ac4ca25b544ad1f92f05.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Nd-YAG Laser in Management of Endobronchial Lesions, a Five - Year Report1925241511ENHamid Reza Jabar DarjaniDepartment of Pulmonary MedicineShideh DabirDepartment of Anesthesiology, NRITLD, Shaheed Beheshti University of Medical Sciences and
Health Services, THERAN-IRAN.Mohammad Omid EdrissianDepartment of Pulmonary MedicineMohammad Reza MasjediDepartment of Pulmonary MedicineJournal Article20210106Background: Nd-YAG laser is a relatively safe and effective procedure in the management of various types of endobronchial lesions including tracheobronchial tumors. It has been used in treatment of benign tumors and as a palliative therapy in obstructive airway lesions due to non-operable lung cancers. Materials and Methods: In this study, patients who underwent laser therapy because of their endobronchial lesions that admitted during 1994-99 in our hospital were investigated. A total number of 210 patients including 14 with benign tumors, 77 with malignant tumors, 11 with metastatic lesions, 14 with undefined prognosis tumor, and 94 with other lesions who seek laser therapy were investigated. The most common signs and symptoms among these patients were cough, dyspnea, hemoptysis, and obstructive pneumonitis. Improvement in airway obstruction following the application of laser therapy was assessed based on clinical signs and symptoms, arterial blood gas indices and spirometric results. Results: After performing laser therapy, cough in 95.1% of patients, dyspnea in 97.7%, hemoptysis in 89.4% and obstructive pneumonitis in all of these patients showed a significant improvement. Obstruction was relieved in more than 95% of the patients; however, this rate reached to 100% in lesions of trachea and main airways. 98% of 263 obstruction sites were relieved immediately after procedure, and 34.6 % of these cases were completely treated by laser therapy. Complications of laser therapy were observed only in 2 of these patients, that resulted in death in one case. Conclusion: The results of our study were consistent with the previous studies regarding the efficacy and safety of Nd-YAG laser therapy in endobronchial lesions. (Tanaffos 2004; 3(9): 19-25)https://www.tanaffosjournal.ir/article_241511_1eec2c82398629cc1ebde8b079d662bb.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Radiographic Manifestations in TB/ HIV Patients3339241513ENMehrdad Bakhshayesh-KaramDepartment of Radiology,Payam TabarsiDepartment of Infectious DiseasesSeyed Mehdi MirsaiediDepartment of Infectious DiseasesMajid Valiollahpour AmiriDepartment of Infectious DiseasesSoheila ZahirifardDepartment of RadiologySeyed Davood MansooriDepartment of Infectious DiseasesMohammad Reza MasjediDepartment of Pulmonary MedicineAli Akbar VelayatiDepartment of Pediatrics,
NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, THERAN-IRAN.Journal Article20210106Background: HIV is the most common risk factor for reactivation of latent TB and is associated with increased rate of progression of infection to disease. Radiological presentation of TB is variable in both HIV (-) and HIV (+) patients but is more in the latter. In this study we describe and analyze radiological presentation of TB/HIV patients in Massih Daneshvari hospital in IRAN. Materials and Methods: We registered the demographic, clinical and laboratory information of TB/HIV patients in MassihDaneshvari hospital between 2002-2003. Inclusion criteria were standard serologic test for HIV (Two positive Elisa test and one positive westernblot test) and proof of TB with clinical and mycobacteriologic or pathologic criteria. Chest x-ray was reported by pulmonary imaging specialist and was divided to two category: Typical (fibrocavitary infiltration in posteroapical segment of upper lobes) and atypical (opacity in middle and lower lobe, hilar and mediastinal adenopathy, pleural effusion, diffuse nodular opacity and normal X-ray). Findings were analyzed using SPSS version 10.5. Results: 15 patients, 13 men (86.7%) and 2 women were included. Mean (±SD) of CD4 count was 229.15 ± 199.45. 53.3% of patients had adenopathy, 26.7% had pleural effusion. Only one patient had cavitary disease. Radiographic pattern was typical in one (6.7%) and atypical in 93.3% of patients. In regard to severity of radiological presentation, mild; moderate and severe pattern was seen in 40%, 26.7% and 33.3% respectively. There was no correlation between severity of radiological presentation and death (p=0.8) and severity of radiological presentation and CD4 count (p=0.53). Conclusion: In this study, it was shown that in spite of some other studies, radiological presentation had not direct correlation with CD4 count; thus, in HIV+ patient, we must consider TB in all atypical radiological presentation regardless of CD4 count. (Tanaffos 2004; 3(9): 33-39)https://www.tanaffosjournal.ir/article_241513_4279692efe1fabefeaf188c351c3b3d2.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Evaluation of Factors Affecting the Tendency towards Cigarette Smoking in High School Students of Tehran4146241514ENGholam Reza HeydariSmoking Cessation Unit, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services,Hooman Sharifi MilaniSmoking Cessation Unit, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services,Mostafa HosseiniDepartment of
Epidemiology and Biostatistic, Institute of Public Health, TEHRAN University of Medical Sciences and Health Services,Mohammad Reza MasjediDepartment of
Pulmonary Medicine, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN.Journal Article20210106Background: Cigarette smoking is the first preventable death in the world. The number of cigarettes smoked per day and the years of smoking are considered as the main risk factors in causing the related disease, mortality, and morbidity. Since it seems that the age at which smoking is started has decreased in our society, it is important to recognize the cause and factors that affect the tendency towards cigarette smoking in this period of life. Materials and Methods: This research was conducted according to WHO questionnaire and Global Youth Tobacco Survey project (GYTS). A total of 1119 high school students were chosen randomly from different educational districts of Tehran from the year 2002 to 2003 and questioned in this regard. Results: 28.2% of students (25.2% female and 30.8% male) smoked occasionally and 4.4% of them (1.5% female and 6.06% male) smoked daily. 67.7% of smoker students started smoking before the age of 15 and 88.7% of them before the age of 17. The most important reason for smoking among 55.3% of students was curiosity and leisurely smoking was observed in 19.3%. Also, presence of a smoker in the family is one of the effective factors that affects the initiation of smoking in students; this was statistically significant (p= 0.000). Conclusion: According to the results of this research, students must be properly trained by appropriate methods in this regard in order to prevent the initiation of smoking in school-aged children. (Tanaffos 2004; 3(9): 41-46)https://www.tanaffosjournal.ir/article_241514_9d2c25ed43dfb15eb0ef277633b02364.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Detection of Burkholderia cepacia Complex in Patients with Cystic Fibrosis4752241515ENSeyed Mohammad EramDepartment of Microbiology, Faculty of Medical Sciences, Tarbiat Modarres UniversityQorban Behzadian NejadDepartment of Microbiology, Faculty of Medical Sciences, Tarbiat Modarres University,Gholam-Reza KhatamiChildren Medical Center, Tehran University of
Medical Sciences and Health Services,Nafiseh NafissiDepartment of Biotechnology, Pasteur Institute, TEHRAN-IRANJournal Article20210106Background: Damaging of the lung function in patients with cystic fibrosis is the most frequent cause of death in these patients. Recently, Burkholderia cepacia has been emerged as an important opportunistic pathogen in these patients; because of its increased isolation from patients with cystic fibrosis since late1970s, the capacity for spread of infection among the cystic fibrosis patient community, its role in damaging lung functions, and its innate multiantibiotic resistance. These different aspects make isolation of Burkholderia cepacia an important task in cystic fibrosis health care settings. Materials and Methods: We examined the capacity of Burkholderia cepacia selective agar (BCSA) as a medium for primary isolation of Burkholderia cepacia samples. Biochemical tests were used to confirm the identification. Results: Burkholderia cepacia strains were isolated from 6 out of 53 respiratory samples as confirmed with biochemical tests. Conclusion: Results of the present study suggest that BCSA can be used as a selective medium with high specificity for primary isolation and identification of Burkholderia cepacia complex bacteria. (Tanaffos 2004; 3(9): 47-52)https://www.tanaffosjournal.ir/article_241515_7e38226e5f028c63794a0d05d08f494d.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Microbiological Pattern and Risk Factors of Bacterial Colonization in Patients with Clinically Stable Boronchiectasis5359241516ENKeyvan Gohari- MoghadamDepartment of Internal MedicineMostafa Alizadeh-ForootanDepartment of Internal MedicineOmid EmadianDepartment of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences and
Health Services, SARI-IRAN.Journal Article20210106Background: Bronchiectasis, dilatation of bronchi with diameter more than 2 mm is a septic and inflammatory process of the lung, caused by infections and systemic or local defense abnormalities of tracheobronchial tree that may lead to destruction of bronchial wall. Infections usually cause inflammatory reaction and destruction of bronchial wall, this further leads to more disturbance in local defense and a vicious cycle of inflammation and bacterial colonization occurs. These bacteria divided to Potentially Pathogen Microorganism (PPM) or non-PPM. The purpose of this study was to find microbiologic pattern and associated (risk) factors in Iranian population and use of more narrow spectrum antibiotics. Materials and Methods: Forty patients with proven diagnosis of bronchiectasis by HRCT in a clinically stable condition fulfilled the inclusion criteria. Fiberoptic bronchoscopy was performed just after spirometry and BAL sampling was achieved. Cut off point of 10000 CFU was considered for positivity of culture media. Results: S. pneumoniae was the predominant pathogen. There was 85% rate of colonization by PPM. We found FEV1< 80% and FVC< 80% as risk factors for bacterial colonization by PPM and S. pneumoniae. Age of diagnosishttps://www.tanaffosjournal.ir/article_241516_7502ffeb942eff088bd084704d743526.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)20040101Whole Lung Lavage under General Anesthesia in A Child with Pulmonary Alveolar Proteinosis (A Case Report)6167241517ENBadiolzaman RadpayDepartment of AnesthesiologyTahereh ParsaDepartment of AnesthesiologySoheila KhalilzadehDepartment of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health
Services, THERAN-IRAN.Shideh DabirDepartment of Anesthesiology,Shahram Karimi ZandiDepartment of Anesthesiology,Mahshid GhasemiDepartment of Anesthesiology,Journal Article20210106Pulmonary alveolar proteinosis (PAP) is a rare disease in which surfactant accumulates abnormally in the pulmonary alveolar walls and causes respiratory symptoms. The only known effective treatment for PAP is pulmonary lavage. We have reported an 11- year-old girl with pulmonary alveolar proteinosis who underwent pulmonary lavage with normal saline under general anesthesia by a new method (using an univent tube for pulmonary blockage, ventilating one lung, and concurrently passing a catheter from out of the tube for lavage). The general condition and vital signs of the patient were normal during lavage and in follow up. Three weeks later, her opposite lung was lavaged too. The results were favorable. (Tanaffos 2004; 3(9): 61-67)https://www.tanaffosjournal.ir/article_241517_8c1fd7848f7f7c3633b9c910582af9c5.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034431(winter)19991130Lung Abscess in Children: A 12-Year Study in National Research Institute of Tuberculosis and Lung Disease241512ENMohammad Reza BoloorsazDepartment of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN.Soheila KhalilzadehDepartment of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN.Arezoo NiknejadDepartment of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN.Arash SafaviDepartment of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN.Ali Akbar VelayatiDepartment of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN.Journal Article19991130Background: Lung abscess is a rare and jeopardizing disease particularly in children. Early diagnosis of the disease can prevent further complications. Delay in diagnosis not only increases the mortality, but also can lead to severe cohttps://www.tanaffosjournal.ir/article_241512_4efe83f439682662c00857eaaa1643bc.pdf