National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Management of MDR-TB: Review of Iran’s Experience615241036ENMohammad Reza MasjediChronic Respiratory Diseases Research CenterPayam TabarsiMycobacteriology Research Center,Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid
Beheshti University of Medical Science,Majid MarjaniClinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid
Beheshti University of Medical Science,Parvaneh Baghaei ShivaClinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid
Beheshti University of Medical Science,Mahshid NasehiCenter for Disease Control and Prevention, Ministry of Health and Medical Education, Tehran, IranMohammad Mehdi GooyaCenter for Disease Control and Prevention, Ministry of Health and Medical Education, Tehran, IranParisa FarniaMycobacteriology Research CenterAli Akbar VelayatiClinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid
Beheshti University of Medical Science,Journal Article20201229https://www.tanaffosjournal.ir/article_241036_690aef3bb5d26482ac756abd57d2ebdd.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Molecular Epidemiology Analysis of TB in Five Regional States of Iran2630241038ENParvaneh RavanMycobacteriology Research Center, National
Research Institute of Tuberculosis and Lung
Diseases (NRITLD), Shahid Beheshti University of
Medical science,Parisa FarniaMycobacteriology Research Center, National
Research Institute of Tuberculosis and Lung
Diseases (NRITLD), Shahid Beheshti University of
Medical science,Nour AmirmozafariDepartment of Microbiology, Iran
University of Medical SciencesKimia TaghaviMycobacteriology Research Center, National
Research Institute of Tuberculosis and Lung
Diseases (NRITLD), Shahid Beheshti University of
Medical scienceMojtaba AhmadiMycobacteriology Research Center, National
Research Institute of Tuberculosis and Lung
Diseases (NRITLD), Shahid Beheshti University of
Medical scienceMohammad Reza MasjediChronic Respiratory
Diseases Research Center,Ali Akbar VelayatiClinical Tuberculosis
and Epidemiology Research Center, National
Research Institute of Tuberculosis and Lung
Diseases (NRITLD), Shahid Beheshti University of
Medical science, Tehran, IranJournal Article20201229Background: The increasing prevalence of TB drug resistant strains in absence of recent transmission evidence, highlights the need for an improved control program, coupled with a need to improve detection rate and early diagnosis. IS6110-RFLP is a means of genotyping TB clinical samples. In this study IS6110- RFLP was used for specification and quick tracking of TB infection source, transmission and reactivation of infection, in Iran. Materials and Methods: This study was carried out on 258 TB patients from Tehran, Mashhad, Isfahan, Shiraz and Ahwaz. DNA from positive cultures was extracted and digested by PVUII restriction enzyme. The digested sequences were separated based on the size on agar gel and then southern Blot was transferred on the membrane. IS6110 probe was marked by HRD and hybridized to the target parts along genome. Results: Sixty-one strains (24%) showed similar patterns (Recent transmission) and 197 strains (76%) showed different IS6110 patterns (Reactivation). Average number of IS6110 copies was between 10-11 bands. Frequency of IS6110 similar pattern was 11.46 in Afghan immigrants and 10.68 in Iranians. Conclusion: High diversity of IS6110, indicates that 76% of the patients have been infected through reactivation by different sources, while 24% have been infected due to recent transmission. Observing different antibiogram patterns in patients infected with the same strain indicated vast transmission of a single strain in the society. A susceptible strain can be changed into mono drug resistant and MDR strain in the transition period.https://www.tanaffosjournal.ir/article_241038_cbaf77bdb06097c58c7141b09c825b4e.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Effects of High-Flux versus Low-Flux Membranes on Pulmonary Function Tests in Hemodialysis Patients3135241039ENAli MomeniDepartment of Internal Medicine, Shahrekord
University of Medical Sciences,Hamid RouhiDepartment of Internal Medicine, Shahrekord
University of Medical Sciences,Glareh KianiKashan University
of Medical Sciences,Masoud AmiriSocial Health Determinants
Research Center and Department of Epidemiology
and Biostatistics, School of Health, Shahrekord
University of Medical Sciences, Shahrekord, Iran.Journal Article20201229Background: Several studies have been carried out to evaluate the effects of dialysis on pulmonary function tests (PFT). Dialysis procedure may reduce lung volumes and capacities or cause hypoxia; however, to the best of our knowledge, there is no previous study evaluating the effects of membrane type (high flux vs. low flux) on PFT in these patients. The aim of this study was the evaluation of this relationship. Materials and Methods: In this cross-sectional study, 43 hemodialysis patients without pulmonary disease were enrolled. In these patients dialysis was conducted by low- and high-flux membranes and before and after the procedure, spirometry was done and the results were evaluated by t-test and chi square test. Results: The mean age of patients was 56.34 years. Twenty-three of them were female (53.5%). Type of membrane (high flux vs. low flux) had no effect on spirometry results of patients despite the significant decrease in the body weight during the dialysis session. Conclusion: High flux membrane had no advantage over low flux membrane in terms of improvement in spirometry findings; thus, we could not offer these expensive membranes for this purpose.https://www.tanaffosjournal.ir/article_241039_70d844f763f1a9c78694fbac16583f95.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Association between Severity of Chronic Obstructive Pulmonary Disease and Lung Function Tests3641241040ENHamid Reza JamaatiTobacco Prevention and Control Research CenterBahareh HeshmatTobacco Prevention and Control Research CenterRonak TamadonTobacco Prevention and Control Research CenterAbbas Hamidi RadTobacco Prevention and Control Research Center,Seyed Amir MohajeraniTracheal Diseases Research Center,Golnar RadmandTobacco Prevention and Control Research CenterEyed Mohammad Reza HashemianChronic
Respiratory Disease Research Center, National
Research Institute of Tuberculosis & Lung Disease,
Shahid Beheshti University of Medical Sciences,
Tehran, IranJournal Article20201229Background: The burden of chronic obstructive pulmonary disease (COPD) is quite high and its prevalence is increasing. We aimed to evaluate the correlation of COPD severity according to the American Thoracic Society (ATS) criteria with spirometric measurements in patients admitted to the emergency ward. Materials and Methods: In this cross-sectional descriptive study, 50 randomly selected patients with COPD admitted to the emergency ward in a tertiary care center were evaluated. The COPD severity according to the ATS criteria was measured and its association with spirometric findings was evaluated. The statistical analysis was performed by SPSS software and the Kendall's tau-b correlation test. Results: The mean age (±standard deviation) was 64.3 ± 11.3 years. Twelve percent were females and 88 percent were males. The COPD severity, according to the ATS criteria, was mild in 16%, moderate in 48%, severe in 32% and very severe in four percent. There was a statistically significant correlation between total lung capacity (TLC) and COPD severity (P=0.013, r=275). Besides, there was a statistically significant correlation between functional residual capacity (FRC) and COPD severity (P=0.022, r=255). Age, sex, and the other spirometric findings especially FEV1 and FVC had no association with COPD severity (P > 0.05). Conclusion: According to the obtained results, it is concluded that determining the COPD severity according to the ATS criteria may help the physicians to estimate the patients' prognosis and therapeutic planning. However, the spirometric measurements may not be replaced by ATS criteria.https://www.tanaffosjournal.ir/article_241040_4091b5179b33d08ca28dd0505c0ea5c4.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Assessment of Airway Resistance in Normal Trained and Fat Untrained Adolescent Boys Influenced by Exercise Experiences4256241041ENMahmoud Asle MohammadizadehDepartment of Sport Physiology, School of Physical
Education & Sport Science, Shahid Chamran
University of Ahwaz - Iran.Mohsen GhanbarzadehDepartment of Sport Physiology, School of Physical
Education & Sport Science, Shahid Chamran
University of Ahwaz - Iran.Abdolhamid HabibiDepartment of Sport Physiology, School of Physical
Education & Sport Science, Shahid Chamran
University of Ahwaz - Iran.Said ShakeriyanDepartment of Sport Physiology, School of Physical
Education & Sport Science, Shahid Chamran
University of Ahwaz - Iran.Journal Article20201229Background: Overweight and obese children are at increased risk of a wide range of health conditions including respiratory diseases. In addition, inactivity can decrease pulmonary function. This study assessed the effect of obesity and inactivity on pulmonary function impairment in adolescents. Materials and Methods: This study was conducted on 80 adolescents. Subjects were divided into two groups. Group I included 40 untrained (VO2max= 29.30±4.20) fat adolescents (UO). Group II included 40 healthy trained (VO2max= 58.11±2.23) normal weight adolescents (TN). Body mass index (BMI), body fat percentage and waist to hip ratio (WHR) were calculated and pulmonary function tests were carried out according to the standard protocols. Data were analyzed using student’s “t” test and Pearson’s correlation coefficient. Results: UO had significantly lower pulmonary function values than the TN group. They also showed lower FEV1/FVC ratio when compared to TN group (p <0.05). In UO group, BMI, body fat percentage and WHR had a significant negative correlation with pulmonary function whereas in TN group only BMI had significant negative correlation with pulmonary function. A significant decrease in FEV1 was observed in the two groups, which led to a decrease in FEV1/FVC% after the exercise compared to before. Thus, exercise test induced airway resistance in both groups. Conclusion: untrained obese adolescents have more respiratory symptoms than their normal weight trained peers, and these factors are recommended to be used as a predictor of pulmonary function in assessment of obese children in epidemiological studies. In addition, obesity and inactivity can surcharge pulmonary function abnormalities in adolescents.https://www.tanaffosjournal.ir/article_241041_5f9480e8531316cd5cbcbd98ecb85d46.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Effects of Intravenous Magnesium Sulfate and Lidocaine on Hemodynamic Variables Following Direct Laryngoscopy and Intubation in Elective Surgery Patients5763241042ENNavid NooraeiDepartment of Anesthesiology, Shahid Beheshti
University of Medical SciencesMasih Ebrahimi DehkordiDepartment of Anesthesiology, Shahid Beheshti
University of Medical SciencesBadiozaman RadpayLung
Transplantation Research Center, National Research
Institute of Tuberculosis and Lung Diseases
(NRITLD), Shahid Beheshti University of Medical
Sciences, Tehran, Iran.Hooman TeimoorianDepartment of Anesthesiology, Shahid Beheshti
University of Medical Sciences,Seyed Amir MohajeraniDepartment of Anesthesiology, Shahid Beheshti
University of Medical Sciences,Journal Article20201229Background: Laryngoscopy and intubation incur hemodynamic changes like increase in heart rate, arterial blood pressure, pulmonary artery pressure, wedge capillary pressure and arrhythmias. Anesthesiologists are continually in search of ways to alleviate such complications. Several medicinal methods have been suggested that serve the purpose including the administration of intravenous magnesium sulfate to minimize these unfavorable responses. This study compares the effects of intravenous administration of lidocaine and magnesium sulfate on unwanted hemodynamic responses following laryngoscopy and intubation in elective surgery candidates. Materials and Methods: This randomized double-blind clinical trial was conducted on 60 ASA-I and ASA-II candidates who received 60 mg/kg (based on Lean Body Mass) magnesium sulfate or lidocaine randomly before intubation. Values of systolic and diastolic blood pressures, mean arterial pressure, and heart rate were recorded for both groups during the 5 minutes following administration, and compared with baseline values. Results: In both groups, systolic blood pressure increased compared to the baseline value. However, there was a significant difference between the two groups as this increase occurred within the first 3 minutes in the lidocaine group, while within the first minute in the magnesium sulfate group. The increase in diastolic blood pressure was not significant. But there was a significant difference in the mean arterial pressure increase between the two groups since in the magnesium sulfate group this increase occurred in the first minute whereas in the lidocaine group it occurred during the first two minutes. There was no significant difference in the heart rates after intubation between the two groups. Conclusion: Magnesium sulfate is more effective than lidocaine in controlling hemodynamics, although it may increase the heart rate.https://www.tanaffosjournal.ir/article_241042_18e70d28646250eed29d6eb8acc942a2.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Using Home Spirometry for Follow up of Lung Transplant Recipients: "A Pilot Study"6469241043ENLida FadaizadehTelemedicine Research Center, National Research
Institute of Tuberculosis and Lung Diseases (NRITLD),
Shahid Beheshti University of medical Sciences,Katayoun NajafizadehLung
Transplantation Research Center, National Research
Institute of Tuberculosis and Lung Diseases (NRITLD),
Shahid Beheshti University of medical Sciences, Tehran,
IranShadi ShafaghiLung
Transplantation Research Center, National Research
Institute of Tuberculosis and Lung Diseases (NRITLD),
Shahid Beheshti University of medical Sciences, Tehran,
IranMahsa Sadat HosseiniTelemedicine Research Center, National Research
Institute of Tuberculosis and Lung Diseases (NRITLD),
Shahid Beheshti University of medical SciencesAzadeh GhoroghiTelemedicine Research Center, National Research
Institute of Tuberculosis and Lung Diseases (NRITLD),
Shahid Beheshti University of medical SciencesJournal Article20201229Background: Lung transplantation is considered the ultimate treatment for some patients, but due to the specific condition of patients undergoing it, follow up is a major concern. The aim of this study was to evaluate the role of home spirometry in follow up of lung transplant recipients and early detection of complications in these patients. Materials and Methods: A PC-based portable spirometry set was used to evaluate the well being of two lung transplant recipients on a regular daily basis for a 6-month period. Patient satisfaction and compliance, and device sensitivity in detecting complications were evaluated. Results of follow up were compared with 2 matched control patients. Results: Patient adherence to home spirometry was 80% in one and 61% in the other patient and both patients were satisfied with the method, although this satisfaction declined towards the end of the study period. The main reason for low adherence was insufficient internet access. This method succeeded in early detection of infectious complications. Conclusion: Home spirometry seems to be a reliable method for follow up of lung transplant recipients, but further studies in a larger group of patients is recommended.https://www.tanaffosjournal.ir/article_241043_6bca6508b109330b366a24c7c560cfd8.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Upper Respiratory System Involvement as the Only Manifestation of Granulomatosis with Polyangiitis in a Child with Marfan Phenotype7477241045ENReza AminDepartment of Allergy and Clinical Immunology,
Namazi Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran.Soheila AlyasinDepartment of Allergy and Clinical Immunology,
Namazi Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran.Tooba MomenDepartment of Allergy and Clinical Immunology,
Namazi Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran.Maryam KhoshkhouyDepartment of Allergy and Clinical Immunology,
Namazi Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran.Sepideh DarougarDepartment of Allergy and Clinical Immunology,
Namazi Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran.Journal Article20201229We report a 9-year old girl with an unusual presentation of granulomatosis with polyangiitis in association with Marfan phenotype. The patient presented with recurrent sinusitis, epistaxis, hearing loss and hyperplastic gingivitis, without any signs or symptoms of major organ involvement.https://www.tanaffosjournal.ir/article_241045_0dd53319c97074d74db0d3668c151afc.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412120130101Pericardial Hydatid Cyst in Oblique Sinus, Obstructing All Pulmonary Veins: A Rare Presentation7880242194ENNeda BehzadniaLung Transplantation Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences,0000-0001-8963-4285Zargam HosseinAhmadiLung Transplantation Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences,Babak Sharif-KashaniLung Transplantation Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences,Faezeh Sheybani-Afshar1 Lung Transplantation Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences,Farah Naghash-ZadehLung Transplantation Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences,Zahra Ansari-AvalPediatric Respiratory Diseases Research
Center, NRITLD, Shahid Beheshti University of
Medical Sciences,Seyed Mohsen MirhosseiniChronic Respiratory Diseases
Research Center, NRITLD, Shahid Beheshti
University of Medical Sciences, Tehran, IranJournal Article20210210Hydatid cyst of the heart is an uncommon presentation of hydatidosis. We present a case of pericardial hydatid cyst in pericardial oblique sinus with extension to posterior wall of left atrium (LA), occluding all pulmonary vein ostia in a 35 year-old female with progressive dyspnea and severe orthopnea.https://www.tanaffosjournal.ir/article_242194_234646a12dca399a4dcb352962a4db29.pdfNational Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-034412119991130The Utility of Metabolic Imaging by 18F-FDG PET/CT in Lung Cancer: Impact on Diagnosis and Staging241037ENAbbas Yousefi-Koma Yousefi-KomaLung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease(NRITLD), Shahid Beheshti University of Medical Sciences,
Tehran, Iran,Mojgan Panah-MoghaddamLung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease(NRITLD), Shahid Beheshti University of Medical Sciences,
Tehran, Iran,Victor KalffAlfred Nuclear Medicine, Melbourne , Monash University, AustraliaJournal Article19991130https://www.tanaffosjournal.ir/article_241037_3a5e5a25f87927c3d5df96c25a53a5bc.pdf