National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran TANAFFOS (Respiration) 1735-0344 24 3 2025 07 01 New Insights on the Relationship Between Body Composition and COPD in Iranian Patients 237 244 739074 EN Somayeh Lookzadeh Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0001-7873-2496 Mansour Rezaei Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Hamidreza Jamaati Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Roqayeh Aliari Ophthalmic Epidemiology Research Center, Shahroud University of Medical Sciences, Shahroud, Iran Mahbube Hemmati Azandaryani Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Vida Mortezaee Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0003-0623-2307 Journal Article 2024 11 20 <strong><span lang="EN-US">Background:</span></strong><span lang="EN-US"> </span><strong><span lang="EN-US">Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory illness with significant systemic effects, notably changes in body composition like muscle atrophy and depletion of fat-free mass (FFM). Such alterations are associated with diminished physical performance, increased exacerbation frequency, and heightened mortality. In the Middle Eastern context, the interplay between body composition and COPD severity remains inadequately explored.</span></strong><span lang="EN-US"> </span><strong><span lang="EN-US">This study investigates the correlation between body composition and COPD severity among Iranian patients, emphasizing anthropometric markers as predictors of disease outcomes.</span></strong> <strong><span lang="EN-US">Materials and Methods: </span></strong><strong><span lang="EN-US">A cross-sectional analysis was conducted involving 184 COPD patients at Dr. Masih Daneshvari Hospital, Tehran. Anthropometric measurements included BMI, triceps skinfold thickness (TSF), mid-upper arm circumference (MUAC), and thigh circumference. Disease severity was evaluated through spirometry and the modified Medical Research Council (mMRC) dyspnea scale. Correlations between these parameters and pulmonary function (FEV1) were assessed using Spearman’s correlation and regression analyses.</span></strong> <strong><span lang="EN-US">Results: </span></strong><strong><span lang="EN-US">Positive associations were identified between FEV1 and BMI (p=0.001), TSF (p=0.004), MUAC (p<0.001), and thigh circumference (p=0.008), indicating that greater anthropometric values predict superior lung function. Negative correlations with mMRC scores highlighted reduced dyspnea severity in participants with healthier body composition. Overweight patients exhibited better spirometric outcomes and fewer exacerbations compared to those underweight.</span></strong> <strong><span lang="EN-US">Conclusion: </span></strong><strong><span lang="EN-US">Anthropometric indices such as BMI and MUAC are instrumental in evaluating COPD severity and guiding individualized management strategies. Further research should validate these findings across broader populations and employ advanced diagnostic tools.</span></strong> https://www.tanaffosjournal.ir/article_739074_7efa3e274261fe0d9680701506812100.pdf