National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran TANAFFOS (Respiration) 1735-0344 23 2 2024 04 01 Variation of Immunoglobulin M and Immunoglobulin G Serum Levels in Seropositive COVID-19 Patients in Mazandaran, Iran: A Six-Month Investigation 183 188 720279 EN Seyed Abbas Mousavi Psychiatry and Behavioral Sciences Research Center, Institute of Addiction, Department of Psychiatry, Mazandaran University of Medical Sciences, Sari, Iran 0000-0003-0953-0705 Faezeh Sadat Movahedi Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 0000-0002-7391-0107 Fatemeh Safari Hajikalai Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 0000-0001-9890-6078 Jamshid Yazdani Charati Department of Biostatistics, Health Sciences Research Center, Institute of Addiction, Mazandaran University of Medical Sciences, Sari, Iran 0000-0002-4721-225X Abolghasem Ajami Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 0000-0002-0062-8792 Seyed Mohsen Soleimani Deputy of Health, Mazandaran University of Medical Sciences, Sari, Iran Zainab Bandalizadeh Health Department, Mazandaran University of Medical Sciences, Sari, Iran. 0000-0001-8398-8461 Saeed Kaviani Charati Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran Journal Article 2023 08 28 <strong>Background: </strong>Forecasting the longevity of patients' immune stability could be the most effective approach to preventing illnesses. This study investigates immunoglobulin M (IgM) serum longevity, immunoglobulin G (IgG), and corresponding risk factors in the first phase seropositive patients in Mazandaran, Iran. <strong>Materials and Methods: </strong>This descriptive cross-sectional study aimed to assess IgM and IgG serum levels in a cohort of 184 seropositive patients during six months. The data analysis involved various statistical methods including descriptive statistics, the chi-square test, independent and paired t-tests, and single and multivariate logistic regression. <strong>Results: </strong>A total of 103 (56%) patients lacked the necessary antibodies, whereas 81 (44%) remained seropositive. According to the results of multivariable logistic regression, patients with a travel history, hospital admissions, and end-stage renal disease (ESRD) had 3.24 (P=0.04), 12.63 (P=0.018), and 9.79 (P=0.001) times higher chances of stable seropositivity, respectively. The average IgG and IgM serum levels fell by 4.5 and 3 units, respectively (P<0.001). In addition, serum levels of IgM and IgG increased by 12% and 12.5%, respectively, and dropped by 75.5% in both serums. There was no increase in either serum level for any of the patients. <strong>Conclusion: </strong>The duration of immune serum stability in patients can significantly reduce disease mortality. The concurrent detection of IgM and IgG antibodies also assists in identifying the infectious stage. https://www.tanaffosjournal.ir/article_720279_29b76ce45d96efd001588eb7496fab17.pdf