National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran TANAFFOS (Respiration) 1735-0344 6 3(summer) 2007 10 01 Generalized Lymphadenopathy: A Case Report of Rosai-Dorfman Disease 65 67 242263 EN Soheila Khalilzadeh Department of Pediatrics, Shirin Karimi Department of Clinical Anatomical Pathology, Mycobateriology Research Center, Atefeh Fakharian Department of Internal Medicine, NRITLD, Shahid Beheshti University, M.C., TEHRAN-IRAN. Seyed Shahin Hakimi Department of Pediatrics, Journal Article 2021 02 12 Sinus histiocytosis with massive lymphadenopathy (SHML), Rosai-Dorfman Disease, is a rare histiocytic syndrome first described by Rosai and Dorfman, seen predominantly in childhood and early adulthood. Even though it is considered a benign disease, fatalities may occur due to cellular infiltrates of SHML. We report a 16–year–old boy with signs of polydypsia, polyuria, weight loss and generalized lymphadenopathy. He had been receiving corticosteroid following the diagnosis of histiocytosis X. Due to hyperglycemia, the patient was admitted with the primary diagnosis of diabetic ketoacidosis and medications were initiated. All paraclinical and immunologic examinations were negative. Axillary lymph node biopsy revealed the diagnosis of Rosai–Dorfman disease. (Tanaffos 2007; 6(3): 65-67) https://www.tanaffosjournal.ir/article_242263_982ac964c46d41c125f5e359b74a6373.pdf