National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran TANAFFOS (Respiration) 1735-0344 4 4(autumn) 2005 12 01 Evaluation of Patients with Infective Endocarditis in a Pulmonary Referral Centre 41 45 241434 EN Neda Behzadnia Cardiology Unit 0000-0001-8963-4285 Payam Tabarsi Department of Infectious Diseases, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN. Babak Sharif Kashani Cardiology Unit Seyed Mehdi Mirsaeidi Department of Infectious Diseases, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN. Majid Valiollahpour Amiri Department of Infectious Diseases, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN. Anahita Alvanpour Department of Infectious Diseases, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN. Seyed Davood Mansoori Department of Infectious Diseases, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN. Journal Article 2021 01 05 Background: Despite the decreased incidence of rheumatic fever and use of prophylactic antibiotic the incidence rate of<br /> infective endocarditis has not declined. In this research, we have studied the clinical feature and therapeutic response of<br /> patients with infective endocarditis presenting with pulmonary manifestations to a pulmonary referral center.<br /> Materials and Methods: All patients with diagnosis of endocarditis that had pulmonary manifestations (based on Duke<br /> Criteria) as their primary clinical presentation were entered in this study. Data in regard to individual information, clinical<br /> features, laboratory finding and therapeutic responses were noted. All data were analysed using SPSS software (version<br /> 11.5).<br /> Results: A total number of twenty patients here entered the study. Mean age was 34.8±11.6 yr. The commonest clinical<br /> features included: fever (95%), cough (65%) and dyspnea (65%). Also the commonest signs were cardiac murmurs (65%),<br /> hepatomegaly (35%) and splenomegaly (35%). Clubbing was seen in 10%. Sixty percent of the cases were intravenous drug<br /> users and 25% were infected with HIV. Also 50% of the patients did not have any background of valvular diseases. However,<br /> there was vegetations on one valve in 75% and multiple valves were involved in 25%. The commonest valves affected were<br /> trocuspid (50%), mitral (30%) and pulmonic valve (10%). Staphylococcus aureus (47.3%) and Streptococcus viridans<br /> (27.3%) were the commonest microorganisms detected. Pericardial effusion was present in 30% which was higher in IV drug<br /> users (p. value=0.042). Total mortality rate in hospital was 5%.<br /> Conclusion: Infective endocarditis should be considered in the list of differential diagnosis in patients suffering from<br /> pulmonary symptoms especially in IV drug users. (Tanaffos 2005; 4(16): 41-45) https://www.tanaffosjournal.ir/article_241434_e613893fe934ebb86a637268b299d65c.pdf