TY - JOUR ID - 245199 TI - Circulating Levels of Monocytic Myeloid-Derived Suppressor Cells (M-MDSC) and CXCL-8 in Non-Small Cell Lung Cancer (NSCLC) JO - TANAFFOS (Respiration) JA - RSPR LA - en SN - 1735-0344 AU - Zadian, Seyed Sajjad AU - M Adcock, Ian AU - Salimi, Babak AU - Mortaz, Esmaeil AD - Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - National Heart and Lung Institute, Imperial College London, London, United Kingdom AD - Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Y1 - 2021 PY - 2021 VL - 20 IS - 1 SP - 15 EP - 21 KW - Myeloid-derived suppressor cells KW - Lung cancer KW - CXCL8 KW - NSCLC KW - SCLC KW - MDSC DO - N2 - Background: Myeloid-derived suppressor cells (MDSC) are categorized as granulocytic (G-MDSCs) and monocytic (M-MDSCs) and their expansion play a role in cancer progression. Recruitment to the cancer site depends upon the presence of a chemoattractant. We aimed to investigate the presence of MDSC subtypes and of interleukin-8 (CXCL-8) in the peripheral blood in lung cancer subtypes including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients. Materials and Methods: Peripheral blood samples of 26 NSCLC patients, 18 SCLC patients, and 8 healthy control donors (HDs) were harvested and the surface expression of CD14, CD15, CD11b, and HLA-DR on MDSCs was measured using flow cytometry. The level of serum CXCL8 was measured by the ELISA method. Results: The frequency of circulating M-MDSCs was significantly higher in patients with NSCLC than in SCLC and HDs. In contrast, there was no statistical difference concerning the frequency of circulating G-MDSCs between the three groups. The concentration of CXCL-8 was significantly higher in the NSCLC and SCLC patients than in HD control with no significant difference between NSCLC and SCLC groups. There was no correlation between serum CXCL8 and G-MDSC levels. Conclusion: Our data confirm a higher frequency of circulating M-MDSCs, but not G-MDSCs, in the blood of those suffering from NSCLC but not for SCLC cases. Measuring MDSC subtypes and serum chemotactic factors may have implications for the differential diagnosis of NSCLC. UR - https://www.tanaffosjournal.ir/article_245199.html L1 - https://www.tanaffosjournal.ir/article_245199_f1a33434ffc0925613b62bac3659e49a.pdf ER -