TY - JOUR ID - 241093 TI - Prevalence of Oseltamivir-Resistant 2009 H1N1 Influenza Virus among Patients with Pandemic 2009 H1N1 Influenza infection in NRITLD, Tehran, Iran JO - TANAFFOS (Respiration) JA - RSPR LA - en SN - 1735-0344 AU - Moradi, Ahmadreza AU - Nadji, Seyed Alireza AU - Tabarsi, Payam AU - Hashemian, Seyed Mohammadreza AU - Marjani, Majid AU - Sigaroodi, Afsaneh AU - Mansouri, Davood AU - Masjedi, Mohammadreza AU - Velayati, Ali Akbar AD - Virology Research Center, AD - Mycobacteriology Research Center AD - Nursing and Respiratory Health Management Research Center AD - Mycobacteriology Research Center, AD - Clinical Tuberculosis and Epidemiology Research Center, AD - Chronic Respiratory Disease Research Center, AD - Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, TEHRAN-IRAN. Y1 - 2011 PY - 2011 VL - 10 IS - 1(winter) SP - 8 EP - 11 KW - Pandemic 2009 H1N1 virus KW - H275Y mutation KW - Oseltamivir-resistance DO - N2 - Background: Oseltamivir-resistant cases were reported during the 2009 pandemic influenza outbreak and therefore, widespread emergence of oseltamivir-resistant 2009 H1N1 virus is imaginable. Underlying medical conditions like immunosuppression increase the chance of oseltamivir resistance. Materials and Methods: In a retrospective cross-sectional study, respiratory tract specimens of confirmed cases of 2009 H1N1 influenza referred to the Masih Daneshvari Hospital were analyzed for presence of H275Y mutation. Results: From November 2009 through March 2010, oseltamivir- resistant 2009 H1N1 infection was observed and confirmed in 4 patients (including 2 immunocompromised patients) by performing H275Y mutation molecular testing. Conclusion: Close monitoring of resistance to neuraminidase inhibitors is essential in tertiary care centers. The H275Y mutation (oseltamivir-resistant genotype) could appear in the absence or presence of selective drug pressure. UR - https://www.tanaffosjournal.ir/article_241093.html L1 - https://www.tanaffosjournal.ir/article_241093_7907d5be5e00035e9361dabd2b29980c.pdf ER -