TY - JOUR ID - 240166 TI - Tuberculosis Control and Role of Molecular Epidemiology Studies in Iran: A Systematic Review JO - TANAFFOS (Respiration) JA - RSPR LA - en SN - 1735-0344 AU - Pourostadi, Mahya AU - Rashedi, Jalil AU - Mahdavi Poor, Behroz AU - Samadi Kafil, Hossein AU - Kazemi, Abdolhassan AU - Asgharzadeh, Mohammad AD - Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - 2Tuberculosis and Lung Diseases Research Center, and Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Biotechnology Research Center, and Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2017 PY - 2017 VL - 16 IS - 3 SP - 190 EP - 200 KW - Molecular Epidemiology KW - Restriction Fragment Length Polymorphisms (RFLP) KW - tuberculosis KW - Transmission KW - Control KW - Iran DO - N2 - Background: Today because of immigration, HIV pandemic and spread of drug resistant tuberculosis, mortality caused by tuberculosis (TB) has increased. To control the disease it is essential to identify the sources of the infection and patterns of transmission. This becomes possible through using molecular epidemiology methods. Materials and Methods: This research reviewed studies based on IS6110- restriction fragment length polymorphism (IS6110-RFLP) as a primary method to recognize the role of molecular epidemiology researches in managing TB in Iran. Within 1995-2015 all human population based studies which had use IS6110-RFLP as the primary method systematically reviewed. Results: At the end, 11 articles were selected. The mean clustering rate obtained was 28.1%. The rate of recent transmission was variable from 2% to 49% and the mean value was determined 17%. Conclusion: The studies revealed that in Iran both reactivation and recent transmission were significant in developing new cases of TB. Yet, reactivation plays greater role. If the matter is supervised insufficiently and carelessly, because of increasing rate of drug resistant TB, immigration of HIV infected individuals, TB especially drug resistant TB will be problematic in the near future. UR - https://www.tanaffosjournal.ir/article_240166.html L1 - https://www.tanaffosjournal.ir/article_240166_5153fa00d8ae1fdd6195f48cd916fe32.pdf ER -