Document Type : Original Article
Authors
-
Amin Daei Sorkhabi
1, 2, 3
-
Aila Sarkesh
1, 2, 3
-
Nader Mohammadzadeh
4, 5, 6
-
Parisa Shiri Aghbash
1, 3, 6
-
Hossein Bannazadeh Baghi
1, 2, 6
1
Immunology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
2
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
4
Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
5
Central Medical Laboratory of East Azerbaijan Province, Tabriz University of Medical Sciences, Tabriz, Iran
6
Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background: The objective of this research is to analyze influenza-induced complications, symptoms, and the interaction of morbidity and mortality rates in hospitalized influenza cases based on age-sex dispersion, influenza virus subtype, prescribed medications, and underlying conditions.
Materials and Methods: We performed this retrospective study using a dataset of 10,517 hospitalized individuals, including 3,101 laboratory-confirmed influenza cases from patients of all ages who had attended hospitals in the Northwest of Iran due to respiratory complications.
Results: The most prevalent strain which circulated annually was influenza A/H3N2. In contrast to previous studies, our findings suggested that influenza A/H1N1 has the highest mortality rate and the most severe complications.
Regardless of virus type/subtype, the most susceptible age group for influenza was 0-9 years old in both males and females. Meanwhile the high-risk age group among males was 50-59 years old and among females were over 80 age group (mortality rate ≈ 20%). Chronic obstructive pulmonary disease (COPD) (32%) and cardiovascular disease (CVD) (30%) were the most prevalent active underlying diseases among the patients who died, with the latter being more prevalent in males over the age of 70. Patients with a history of chemotherapy had the highest mortality rate. Patients who were prescribed a combination of antibiotics and antivirals had better outcomes with lowest mortality rate.
Conclusion: Our findings demonstrated that annual influenza seasons are often marked by changes in influenza types and subtypes, with variations in the severity. Development of a standardized set of arrays that best correspond with infections, can be useful in guiding diagnostic and therapeutic decisions.
Keywords
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