Department of Nutrition, Tabriz University of Medical Sciences and Health Services
Department of Infectious Diseases
Department of Clinical Anatomical Pathology,
Department of Infectious Diseases,
Department of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services.
Background: The effects of vitamins on human immune system have been well studied. Vitamin A deficiency and its effects on immune system in pulmonary tuberculosis (TB) patients have been established. This study was carried out to evaluate vitamin A supplementary effect on immunologic profile of tuberculosis patients. Materials and Methods: In a double-blind clinical trial, thirty-five patients with confirmed pulmonary tuberculosis were included. The case group received vitamin A injection, 50000 lU, every 10 days for two months along with standard treatment of TB; the control group received only anti-TB drugs. Immunologic profiles including CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, HLA-DR, CD16+56+, and plasma vitamin A as well as nutritional status were assessed in both groups primarily and two months after above-mentioned treatments. Data were analysed using SPSS software version 10. Results: The study showed that there were not significant differences in mean(± SD) of age, body weight, height, body mass index (BMI), fat thickness and vitamin A plasma level between the vit A-receiving and control groups. The mean of peripheral blood CD3+ showed significant increase in patient-control group [71.8 ±7.9 % lymphocytes (after supplementation) compared with 68.3 ±10.7% (before supplementation); p= 0.014.]. This was also true about CD4+ (p= 0.001). CD4+ to CD8+ ratio and the mean of CD19+ showed significant decrease in the patient control group and the vit A-receiving group, respectively (p= 0.002 and p= 0.04, respectively). In contrast, there was an increased significant difference for CD+16+56+ mean in the above-mentioned groups which was more prominent in the vit A- receiving group (p=0.038). The means of HLA-DR and CD8+ did not show significant differences in both groups before and after supplementation. Conclusion: It seems that vitamin A supplementary effects on the quality of lymphocytic markers are remarkable. However, further studies should be performed regarding immunologic response quality. (Tanaffos 2005; 4(14):53-60)