National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Role of P2X7 Receptors in Release of IL-1β: A Possible Mediator of Pulmonary Inflammation611241061ENEsmaeil MortazDivision of Pharmacology, Utrecht Institute for
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, The Netherlands,Chronic
Respiratory Disease Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences, Tehran, IranIan M AdcockCell and Molecular
Biology Group, Airways Disease Section, National
Heart and Lung Institute, Imperial College London,
UKHamed ShafeiDivision of Pharmacology, Utrecht Institute for
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, The Netherlands,Mohammad Reza MasjediChronic
Respiratory Disease Research Center, National
Research Institute of Tuberculosis and Lung Disease
(NRITLD), Shahid Beheshti University of Medical
Sciences, Tehran, IranGert FolkertsDivision of Pharmacology, Utrecht Institute for
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, The Netherlands,Journal Article20201229Extracellular ATP is a signaling molecule which plays an important role in alerting the immune system in case of any tissue damage. Recent studies show that binding of ATP to the ionotropic P2X7 receptor of inflammatory cells (macrophages and monocytes) will induce caspase 1 activation. Stimulation of caspase 1 activity results in maturation and release of IL-1 in the inflammasome in Chronic Obstructive Pulmonary Disease (COPD) patients. COPD is an inflammatory disease characterized by emphysema and/or chronic bronchitis and is mostly associated with cigarette smoking. It is one of the leading causes of death in humans and there is currently no medication to stop the progression of disease. A deeper understanding of the mechanism by which the P2X7 receptor triggers IL-1 maturation and release, may open new opportunities for the treatment of inflammatory diseases such as COPD.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Proline-Glycine-Proline as a Potential Biomarker in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis1215241062ENArne Lucas Ten HoeveDivision of Pharmacology, Department of
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, NetherlandsMojtaba Abdul RodaDivision of Pharmacology, Department of
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, NetherlandsFrank RedegeldDivision of Pharmacology, Department of
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, NetherlandsGert F OlkertsDivision of Pharmacology, Department of
Pharmaceutical Sciences, Faculty of Science, Utrecht
University, Utrecht, NetherlandsJames Edwin BlalockDivision of
Pulmonary, Allergy and Critical Care Medicine,
Department of Medicine, University of Alabama at
Birmingham, Birmingham, Alabama, USAAmit GaggarDivision of
Pulmonary, Allergy and Critical Care Medicine,
Department of Medicine, University of Alabama at
Birmingham, Birmingham, Alabama, USAJournal Article20201229The present review discusses the role of tri-peptide Proline –Glycine -Proline (PGP) as a potential player, biomarker and therapeutic target in this process.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Effect of Age on Response to Treatment in Adult Patients with Severe Persistent Asthma1621241074ENEbrahim RaziDepartments of Internal Medicine, Kashan University
of Medical Sciences, Kashan, Iran.Gholam Abbass MoosaviDepartments of Internal Medicine, Kashan University
of Medical Sciences, Kashan, Iran.Armin RaziDepartments of Internal Medicine, Kashan University
of Medical Sciences, Kashan, Iran.Journal Article20201230Background: Due to current controversies regarding the effect of age on response to treatment in asthmatic patient, the present study was performed on patients referred with acute asthma attack for further evaluation of this matter. Materials and Methods: In this study 138 patients with severe persistent asthma were enrolled and divided into two categories of young (age ≤35 yrs; 82 cases, mean age = 25.2±7.3 years) and elderly subjects (≥50 yrs; 56 cases, mean age 57.4±6.4 years). Response to treatment was determined by pulmonary function tests. Results: The mean percentage change of FEV1 from baseline in male and female patients of young and old age was 75.05±46.61 and 71.39±41.30%, (P=0.721) and 100.79±51.34% and 69±37.39% (P=0.015), respectively. The mean percentage of possible improvement of FEV1 among male and female patients of young and old age was 62.81±25.67% and 54.46±23.82% (P=0.148), and 78±24.04% and 63.58±41.24% (P=0.087); respectively. Conclusion: Response to treatment was significant in both young and old age groups suffering from acute asthmatic attack except for young female patients in which, percentage change of FEV1 increased compared to older patients. Among other patients this value and percentage of possible improvement of FEV1 between the 2 groups did not change significantly and age did not play a significant role in assessing the response to treatment in acute asthmatic attack.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601The Relationship between COPD Assessment Test (CAT) Scores and Severity of Airflow Obstruction in Stable COPD Patients2226241075ENHassan GhobadiDepartment of Internal Medicine, Pulmonary
Division,Saeid Sadeghieh AhariDepartment of Community Medicine,
Ardabil University of Medical Sciences, Ardabil, Iran,Azadeh KameliDepartment of Internal Medicine, Pulmonary
Division,Sharzad M.LariDepartment of Internal Medicine, Pulmonary
Division, Mashhad University of Medical Sciences,
Mashhad, Iran.Journal Article20201230Background: COPD is a major cause of morbidity in smokers. The COPD assessment test (CAT) is a validated test for evaluation of COPD impact on health status. CAT is not a diagnostic test and pulmonary function test (PFT) still remains the most important diagnostic test. However, its predictive value for evaluation of disease impact is weak. The purpose of this study was to determine the relationship between CAT score and PFT in COPD patients. Materials and Methods: We evaluated 105 patients with stable COPD. Demographic data were obtained at baseline. Severity of airflow obstruction was assessed by standard spirometry and classified by the Global initiative for Obstructive Lung Disease (GOLD) criteria. Then, the impact of COPD on health status was assessed using CAT. The CAT scores were categorized into four groups. We statistically compared the relationship between CAT score, COPD stages, CAT groups and PFT. Results: The mean age of patients and mean period of smoking (p/y) were 59.60±11.93SD and 35.43±15.33 SD yrs, respectively. The mean FEV1%predicted was 71.01±26.70SD.The mean CAT score was 19.61±8.07 SD. The correlation between the severity of smoking and GOLD classification was significant (p=0.006).There was a significant association between the FEV1%predicted and total CAT score (r= -0.55, p < 0.001). The correlation between mean FEV1%predicted and mean score of CAT groups 1, 2, 3, and 4 was statistically significant (p <0.001). Conclusion: The relationship between CAT score and FEV1%predicted suggests that CAT is linked to severity of airflow limitation and GOLD classification in stable COPD patients. Health status as measured by CAT worsens with severity of airflow limitation.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Outcome of the Surgical Treatment of Bullous Lung Disease: A Prospective Study2733241076ENYasir Ahmad LoneSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaAbdul Majeed DarSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaMukand Lal SharmaSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaIrfan RobbaniSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaArif Hussain SarmastSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaEnas MushtaqSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaMohammad Yousuf KachrooSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaOmar Masood KhanSher-i-Kashmir Institute of Medical Sciences,
Srinagar, IndiaJournal Article20201230Background: This study aimed at evaluating the outcome of surgery for bullous lung disease by comparing the preoperative and postoperative subjective dyspnea score, pulmonary function and clinical features. Materials and Methods: This prospective study was conducted from May 2009 to October 2011, on 54 patients operated for bullous lung disease. Follow-up at 3-6 months consisted of taking a comprehensive history, physical examination, radiological work-up, and evaluation of changes in subjective dyspnea score, arterial blood gas analysis (ABG), and pulmonary function test (PFT). After comparison with preoperative values, the student’s paired t-test was used to calculate the statistical significance. Results: With approximately 21.6 cases per year, the most common underlying lung pathology was primary bullous lung disease, followed by COPD. The most common presenting complaint was spontaneous pneumothorax in tall young adults in their fourth decade of life with a history of smoking. Bullectomy, with or without decortication, was done for all cases. Improvement in mean PaO2 (arterial partial pressure of oxygen), SaO2 (arterial oxygen saturation) and PaCO2 (arterial partial pressure of carbon dioxide) was seen in most cases but was statistically insignificant. Improvement in mean FEV1 (forced expiratory volume in 1st second), FVC (forced vital capacity) and FEV1 / FVC was statistically significant, with FEV1 being the most reliable indicator of postoperative progress. Improvement in subjective dyspnea score was statistically significant and showed an inverse correlation with FEV1. Those with diffuse pulmonary parenchymal involvement had poorer baseline values and less significant postoperative improvement. Complications occurred more commonly in those with diffuse disease. Mortality was seen exclusively in those with diffuse disease. Conclusion: We conclude that surgery is required for bullous lung disease more frequently in our community since we have a high number of young patients with primary bullous lung disease and localized parenchymal involvement and these patients have a good surgical outcome. Potentially fatal complications like pneumothorax and recurrent infections can therefore be prevented in them. Those with underlying diffuse disease and severely decreased FEV1 (especially below 1 L) also benefit from surgery but require careful patient selection.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Pattern of Pulmonary Function Test Abnormalities in Anthracofibrosis of the Lungs3437241077ENMajid MirsadraeeDepartment of Internal Medicine, Islamic Azad
University – Mashhad Branch, Mashhad, Iran,Amir AsnaashariDepartment of Pulmonary Medicine, Mashhad
University of Medical Sciences, Mashhad, Iran.Davood AttaranDepartment of Pulmonary Medicine, Mashhad
University of Medical Sciences, Mashhad, Iran.Journal Article20201230Background: The objective of this study was to discuss the spirometric characteristics of anthracofibrosis which is a from of bronchial anthracosis associated with deformity. Materials and Methods: Forty anthracofibrosis subjects who were diagnosed with bronchoscopy were enrolled in this prospective study. Static and dynamic spirometry plus lung volumes and diffusion capacity were measured in this group and compared to a healthy control group. Results: Dyspnea (95%), cough (86%) and wheezing (68%) were the most frequent clinical findings. Spirometry showed significant decrease in all parameters including VC (FVC), FEV1, FEV1/FVC, FEF25-75 and FEF25-75 /FVC. The low value of FEV1/FVC and FEF25-75 and the increment of RV were in favor of obstructive patterns in 95% of subjects. Improving the obstruction with bronchodilator was not significant and diffusion capacity was mostly normal. Conclusion: Anthracofibrosis should be added to the list of chronic obstructive pulmonary diseases.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Silicosis among Stone- Cutter Workers: A Cross-Sectional Study3841241078ENMashaallah AghilinejadDepartment of Occupational Medicine, Faculty of
Medicine, Occupational Medicine Research Center,
Tehran University of Medical Sciences (TUMS),
Tehran, IranAli NaserbakhtOccupational Medicine Research Center,
Tehran University of Medical Sciences (TUMS),
Tehran, IranMorteza NaserbakhtOccupational Medicine Research Center,
Tehran University of Medical Sciences (TUMS),
Tehran, IranGhavamedin AttariOccupational Medicine Research Center,
Tehran University of Medical Sciences (TUMS),
Tehran, IranOccupational HygienistJournal Article20201230Background: Production process of most factory-made products is harmful to our health and environment. Silica is the most important stone used in stone cutting factories. Numerous researches have reported respiratory diseases due to the inhalation of these particles in various occupations. Silicosis is a disease with typical radiographic pattern caused as the result of inhalation of silica particles. According to the intensity of exposures and onset of initiation of clinical symptoms silicosis is classified into three groups of acute, chronic and accelerated forms. The present study evaluated silicosis among stone cutter workers. Materials and Methods: This cross sectional study was performed on stone cutter workers in Malayer city (Azandarian) between 2008 and 2009. Respiratory data of our study participants were collected with a respiratory questionnaire and performing spirometry tests and chest radiography. Results: Among our participants, 16 silicosis cases were diagnosed by radiographic changes. Among them, 10 workers had exposure for more than three years and 6 workers were smokers. Eleven workers had an abnormal radiographic pattern on their chest x-rays. Seven workers had obstructive and 4 workers had restrictive spirometric patterns. Conclusion: Prevalence of silicosis was high among our understudy workers and preventive strategies are required to control it.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Balloon Bronchoplasty: Case Series4248241079ENHamid Reza JabbardarjaniTracheal Diseases Research Center,Arda KianiTracheal Diseases Research Center,Negar SheikhiTracheal Diseases Research Center,Azadeh ArabTracheal Diseases Research Center,Mohammad Reza MasjediChronic
Respiratory Diseases Research Center, NRITLD,
Shahid Beheshti University of Medical Sciences
Tehran, Iran.Journal Article20201230Central airway stenosis may be a manifestation of benign or malignant lesions and can be a life threatening condition. There are different surgical and endoscopic modalities for treatment of these lesions. Balloon bronchoscopy is an interventional pulmonologic modality and can be performed under direct vision or fluoroscopic guidance. This technique can be used along with other interventional modalities for treatment of patients with tracheal stenosis. In this study we report balloon bronchoscopy as an interventional modality in a series of patients with tracheal stenosis and assess the outcome.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Systemic AL Amyloidosis of the Tracheobronchial Tract and Lungs: a Rare Finding4953241080ENInès ZendahAbderrahmane Mami Hospital of Thoracic Diseases.
Department I of Pneumology. 2080. Ariana, Tunisia.Mouna Ben KhelifaAbderrahmane Mami Hospital of Thoracic Diseases.
Department I of Pneumology. 2080. Ariana, Tunisia.Aïda AyadiAbderrahmane Mami Hospital of Thoracic Diseases.
Department of Pathology. 2080. Ariana, zunisia.Amel KhattabAbderrahmane Mami Hospital of Thoracic Diseases.
Department I of Pneumology. 2080. Ariana, Tunisia.Saoussan HantousAbderrahmane Mami Hospital of Thoracic Diseases.
Department of Radiology. 2080.Ariana, Tunisia.Habib GhediraAbderrahmane Mami Hospital of Thoracic Diseases.
Department I of Pneumology. 2080. Ariana, Tunisia.Journal Article20201230A 67- year old man presented with cough, weight loss and night sweats. Fiberoptic bronchoscopy did not show any abnormality. Chest computed tomography scan revealed peribronchovascular thickening, sheathing and narrowing of some bronchi. There were also mediastinal and interbronchial Lymphadenopathies. The patient became lost to follow-up. He presented 5 years later with pneumonia. Flexible bronchoscopy showed diffuse infiltration of the bronchi suggesting lung cancer. Histopathological study with histochemical staining revealed tracheobronchial tract AL amyloidosis. Chest CT-scan revealed extension of the broncho-vascular thickening and superimposed pulmonary calcified nodules and lymphadenopathies. Labial biopsy revealed AL amyloidosis. No specific treatment of amyloidosis was thought to be necessary for the patient. At 6 years follow-up the disease had not progressed. This case report highlights the fact that even very rarely, systemic AL amyloidosis can involve the tracheobronchial tract. Moreover, the lungs and the tracheobronchial tract can, although rarely, be affected in the same patient.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Acute Respiratory Failure as a Rare Complication of Celiac Plexus Block in a Patient with Adenocarcinoma of the Ampulla of Vater5457241081ENBadiozaman RadpayLung Transplantation Research Center,Department of Anesthesiology,Tahereh ParsaTelemedicine
Research Center,Shideh DabirChronic Respiratory Diseases
Research Center, NRTLD, Shahid Beheshti
University of Medical Sciences, Tehran-Iran.Seyed Masoud HashemiDepartment of Anesthesiology,Journal Article20201230Celiac and splanchnic plexus blocks are considered as terminal approaches for pain control in end stage pancreatic cancer. It may be done temporarily (using local anesthetics) or as a permanent act (using alcohol and/or phenol). Like every other interventional procedure, celiac plexus block has its own potential complications and hazards among them pneumothorax and ARDS are very rare. In this case report we present an end stage patient with adenocarcinoma of ampulla of Vater with involvement of both abdomen and thorax who presented with severe intractable abdominal pain. Bilateral celiac plexus block in this patient resulted in left side pneumothorax and subsequent development of ARDS. We discuss the rare complications of celiac plexus block as well.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601Mediastinal Lymphangioma in a Child5860242202ENSoheila KhalilzadehPediatric Respiratory Diseases Research Center,Maryam HassanzadPediatric Respiratory Diseases Research CenterAli CheraghvandiChronic Respiratory Diseases Research Center,Mihan Pour AbdollahPediatric Respiratory Diseases Research Center,Amir Ali KhodayariPediatric Respiratory Diseases Research Center,Mojtaba JavaherzadehLung Transplantation Research Center, NRITLD,
Masih Daneshvari Hospital, Shahid Beheshti
University of Medical Sciences, Tehran , Iran.Journal Article20210210We report a case of a male child with a cystic mass in his left side of the neck with extension to the mediastinum. This article highlights the clinical and paraclinical findings and management of these cases. In conclusion, it is necessary to evaluate the mediastinum for extension of the cyst in cases with cystic hygromas of the neck. Surgical resection of the tumor through a cervical incision can be considered.National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTANAFFOS (Respiration)1735-0344112(spiring)20120601A 35-Year-Old Man with Dyspnea and Hemoptysis6163242203ENIlad Alavi DarazamDepartment of Internal Medicine, Division of
Infectious Disease and Clinical Immunology,Chronic
Respiratory Disease Research Center,Farid AziziDepartment of Internal Medicine, Division of
Infectious Disease and Clinical Immunology,Katayoon NajafizadehLung
Transplantation Research Center,Davood MansouriDepartment of Internal Medicine, Division of
Infectious Disease and Clinical Immunology,Clinical
Tuberculosis and Epidemiology Research Center,
NRITLD, Shahid Beheshti University of Medical
Sciences, Tehran, IranJournal Article20210210