2024-03-28T19:29:17Z
https://www.tanaffosjournal.ir/?_action=export&rf=summon&issue=32701
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Immunopathogenesis of Pneumonia in COVID-19
Shamila D.
Alipoor
Hamidreza
Jamaat
Payam
Tabarsi
Esmaeil
Mortaz
Coronavirus disease 2019 (COVID-19), caused by a member of the Coronaviridae family (SARS-CoV-2), was initially reported in Wuhan, China in late December and spread rapidly around the world, reaching a pandemic level (1). This disease has been diagnosed in almost 4.44 million people globally, resulting in more than 302,000 deaths until 15 May, 2020 (2). In Iran, a total of 115,000 confirmed cases of COVID-19 were reported until May 2020, with a fatality rate of 5.118%. Coronaviruses are enveloped positive-stranded RNA viruses with an approximate size of 80-120 nm. They contain the longest viral RNA genomes of all RNA virus families (3). The whole genome sequence of this novel virus contains 29,903 nucleotides. SARS-CoV-2 is closely related to bat-derived SARS-like coronaviruses, sharing 79% nucleotide identity with SARS-CoV (4, 5). Also, viral capsid proteins, including spike glycoprotein (S protein), play an important role in the cell entry and tropism in patients with COVID-19 (6). Overall, coronaviruses use a variety of receptors to enter the cells. Recent evidence shows high homology between SARS-CoV and SARS-CoV-2, as SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its receptor, similar to SARS-CoV (7).
2020
04
01
79
82
https://www.tanaffosjournal.ir/article_239521_5d4e537d22c6f6fe8d41c4b1ba6b2a13.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Clergymen in Hospitals as Patient Companions during the COVID-19 Pandemic
Reza
Aminnejad
Hamed
Shafiee
Reza
Heidarifar
Rosa
Alikhani
As of December 2019, a new pandemic disease, called coronavirus disease-2019 (COVID-19), is spreading rapidly around the world (1). On February 19, Iran reported the first case of COVID-19 infection (2). Similar to previous outbreaks of infectious diseases, anxiety, besides other symptoms, was a common finding in hospitalized patients in Qom, Iran, which was also reported in patient companions (3). The unexpected workload, alongside limited human resources, particularly the nursing staff, was a common problem in most hospital wards during the early weeks of the outbreak.A few weeks following the COVID-19 crisis, a volunteer group of clergymen, trained for primary personal protective measures, replaced the patient companions in Nekooei-Hedayati-Forghani Hospital. After one week, the patients, nurses, and physicians were asked if they were satisfied with the presence of volunteer clergymen as patient companions. The results showed that 92.9% of patients were satisfied with the presence of clergymen, while only 2% were unhappy. Fear of disease transmission to the volunteered companions and others (particularly families) was the only reason for the patients’ dissatisfaction. On the other hand, the reasons for the patients’ satisfaction with the presence of clergymen were overcoming the feeling of loneliness, reduction of fear and anxiety, and promotion of spiritual well-being.
2020
04
01
83
84
https://www.tanaffosjournal.ir/article_239528_4b4521872f21aa56613d25e89db33c20.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Bruton's Tyrosine Kinase: A Promising Target for the Treatment of COVID-19
Mitra
Rezaei
Abdolreza
Babamahmoodi
Majid Marjani
Marjani
Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in China and quickly spread throughout the world. By June 24, 2020, the World Health Organization (WHO) reported the total number of 8,993,659 laboratory-confirmed cases leading to 469,587 deaths worldwide (1). COVID-19 has a range of clinical manifestations from asymptomatic cases to severe and life-threatening illnesses (2). The most severe form of the disease is the rapidly progressing failure of the respiratory system, presenting by severe dyspnea and profound hypoxemia, and may lead to acute respiratory distress syndrome (ARDS)(3) .The pathophysiology of COVID-19 is under investigation and has not yet certainly defined. Like other severe forms of coronavirus diseases, the hyperactivation of the immune system resulting in hyper inflammation and cytokine storm syndrome has been postulated (4) . Most of the patients with the severe form of COVID-19 have higher serum levels of various inflammatory cytokines and chemokines, including interleukin-1β (IL-1β), IL-6, granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), interferon-γ (IFN-γ), tumor necrosis factor (TNF), and macrophage inflammatory protein-1α (MIP1α)(5, 6) .
2020
04
01
85
88
https://www.tanaffosjournal.ir/article_239530_afa3e08ed295fbe5ff7e0edd56ceb012.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Triage Management of Patients during the Outbreak of Coronavirus Disease 2019 (COVID-19)
Reza
Shirvani
Reza
Heidarifar
Roghayyeh
Ahangari
Monireh
Mirzaie
Mahboubeh Sadat
Yousefi
Coronavirus disease 2019 (COVID-19), as a rapidly growing pandemic, was first reported in Iran on February 19, 2020 (1). Following the pandemic, with the spread of fear by social media, people rushed to stock up on goods, and even many rushed to hospitals and clinics. Triage of patients in emergency departments is of particular importance, as these departments have always been on the front line of care for patients. Therefore, if the triage system is not efficient, it can lead to overcrowding in hospitals (2). This overcrowding can result in the exhaustion of the medical staff, loss of patients, missing the required tests for patients, and anxiety in patients.Overcrowding caused by erroneous triage decisions may predispose uninfected patients with contagious diseases to COVID-19 (3, 4). Accordingly, specific hospitals were initially designated to patients with COVID-19 in every city so that patients with severe conditions, such as myocardial infarction (MI), cerebrovascular accidents (CVAs), traumas, and other diseases, could be referred to other hospitals to prevent the spread of infection. Overall, the greatest challenge was the large number of patients, referred to the designated hospitals with symptoms of common cold, flu, and COVID-19.
2020
04
01
89
90
https://www.tanaffosjournal.ir/article_239531_5fa5075d1c797932cedcf630c476c25a.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
NRITLD Protocol for the Management of Patients with COVID-19 Admitted to Hospitals
Majid
Marjani
Payam
Tabarsi
Afshin
Moniri
Seyed Mohammadreza
Hashemian
Seyed Alireza
Nadji
Zahra
Abtahian
Majid
Malekmohammad
Arda
Kiani
Behrooz
Farzanegan
Alireza
Eslaminejad
Atefeh
Fakharian
Jalal
Heshmatnia
Atefeh
Abedini
Sharareh
Seifi
Fatemeh
Yassari
Maryam Sadat
Mirenayat
Mitra
Rezaei
Hakimeh
Sheikhzade
Zargham Hossein
Ahmadi
Farzaneh
Dastan
Mohsen
Sadeghi
Somayeh
Lookzadeh
Mihan
Porabdollah
Elham
Askari
Parvaneh
Baghaei
Babak
Mansourafshar
Alireza
Jahangirifard
Maryam
Vasheghani
Mojtaba Mokhber
Dezfuli
Mohammad
Varahram
Hamidreza
Jamaati
Davood
Mansouri
Alireza
Zali
Ali Akbar
Velayati
In December 2019, the first case of coronavirus disease 2019 (COVID-19), was reported from China. An emerging infectious disease caused by a new strain of coronavirus, namely severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to a global health problem and pandemic (1).By 28 May 2020, the total number of laboratory-confirmed cases of COVID-19 surpassed 5,701,337, with 357,688 reported deaths worldwide (2). Iran reported its first confirmed cases of COVID-19 on the 19 February 2020 in Qom, Qom Province (3), and by 29 May 2020, a total of 143,849 confirmed cases and 7627 deaths were reported (2).
2020
04
01
91
99
https://www.tanaffosjournal.ir/article_239587_c1bde58400af5ad873a71054536f46e0.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Radiological Mimickers of COVID-19 Pneumonia: A Pictorial Review
Mehrdad
Bakhshayeshkaram
Sara
Haseli
Pooya
Iranpour
Computed tomography (CT) scan plays an important role in the early diagnosis of coronavirus disease (COVID-19) pneumonia. In resource-limited regions with limited availability of polymerase chain reaction (PCR) kits, CT findings, together with appropriate clinical parameters, are used to establish an accurate diagnosis. However, since the radiological findings are non-specific, the CT features may overlap with the findings of several other categories of pulmonary diseases. Diagnosis based on radiological features can be especially challenging in the presence of a comorbid lung disease. This study aimed to describe the radiological findings of a wide spectrum of lung pathologies, with emphasis on their similarities with the common presentations of COVID-19 pneumonia.
COVID-19
Coronavirus
Tomography, X-ray computed tomography
2020
04
01
100
107
https://www.tanaffosjournal.ir/article_239627_0428a8dda221f1773bc4828b56144ccc.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
A Novel Coronavirus Disease (COVID-19): a Review of Host Cell Signaling Pathways
Hadiseh
Mohammadpour
Ali
Ziai
Makan
Sadr
Mitra
Rezaei
Majid
Marjani
Payam
Tabarsi
Coronaviruses (CoVs) are the largest group of positive-sense RNA viruses. By increasing our understanding of the interactions between CoVs and the host innate immune system, we can evaluate the development and persistence of inflammation in the lungs and reduce the risk of CoV-induced lung inflammation with a new group of genetic variants. Here, we aim to discuss some recent changes in host cell factors that may be used by CoV to promote the proliferation cycle. We also discuss different host cell signaling pathways that can be considered in the host-pathogen interactions at the molecular level. The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created new challenges for the cultural, economic, and health infrastructures. Therefore, it is important that healthcare systems and physicians recognize a global integrated framework for monitoring the progression of COVID-19 to develop targeted therapies that can potentially save human lives.
Coronavirus
Host-pathogen interactions
Signaling pathways
2020
04
01
108
111
https://www.tanaffosjournal.ir/article_239654_b32e8a8a057beef0999b0009450de9bf.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Real Clinical Practice and Therapeutic Management Following COVID-19 Crisis in two Hospitals in Iran: A Statistical and Conceptual View
Ali
Najafi
Mostafa
Ghanei
Ghasem
Janbabaei
Ali Akbar
Velayati
Seyed Hassan
Saadat
Hamidreza
Jamaati
Payam
Tabarsi
Farzaneh
Dastan
Malihe
Ram
Enayat
Darabi
Saeid
Fathi
Mohammad Gholami
Fesharaki
Amir Hosein
Ghazale
Shahrzad
Saloo
Background: The Coronavirus disease 2019 (COVID-19) outbreak quickly has spread and became a pandemic. However, no approved therapeutics or effective treatment is available for the treatment of these patients. The present study was done to retrospectively assess the treatment strategies (e.g., pharmaceutical care services) for COVID-19 patients in selected hospitals and highlight the importance of such services in the management of a pandemic.Materials and Methods: Data from a series of COVID-19 patients (978 patients; 658 males [66.9%] and 324 females [33.1%]) admitted to the selected hospitals in Tehran from 20 February to 19 March 2020 were retrieved retrospectively from the Health Information System (HIS) of the hospitals. The statistical tests were used for analyzing the effect and correlation of the variables (drugs) with the average length of stay (ALOS) in the hospital.Results: Diverse medication classes and old drugs with or without strong evidence of therapeutic effects against the novel coronavirus, some previously tried as a treatment for SARS-CoV and MERS-CoV, were mostly used for the treatment of patients in the hospitals. Many medications (broad-spectrum antibiotics and antivirals) or combination therapies are used without evidence of their therapeutic effects during pandemics.Conclusion: Therefore, guidelines should be provided for the off-label use of these drugs by policymakers and stakeholders during a pandemic emergency due to high demands. Also, monitoring of the HIS data can play an important role in improving public health response to emerging diseases.
COVID-19
Treatment Strategies
Hospital Information System (HIS)
2020
04
01
112
121
https://www.tanaffosjournal.ir/article_239705_94cc38e713745862617d908e71fddd98.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Clinical Manifestations of Patients with Coronavirus Disease 2019 (COVID-19) in a Referral Center in Iran
Parvaneh
Baghaei
Seyed Alireza
Nadji
Majid
Marjani
Afshin
Moniri
Seyed Mohammadreza
Hashemian
Hakimeh
Sheikhzade
Zahra
Abtahian
Jalal
Heshmatnia
Atefeh
Abedini
Hamidreza
Jamaati
Babak
Mansourafshar
Zargham Hossein
Ahmadi
Mojtaba Mokhber
Dezfuli
Sharareh
Seifi
Mohsen
Sadeghi
Maryam Sadat
Mirenayat
Fatemeh
Yassari
Somayeh
Lookzadeh
Behrooz
Farzanegan
Arda
Kiani
Maryam
Vasheghani
Farzaneh
Dastan
Alireza
Eslaminejad
Majid
Malekmohammad
Mohammad
Varahram
Alireza
Zali
Payam
Tabarsi
Ali Akbar
Velayati
Background: Following the recent epidemic of coronavirus disease 2019 (COVID-19) in Wuhan, China, a novel betacoronavirus was isolated from two patients in Iran on February 19, 2020. In this study, we aimed to determine the clinical manifestations and outcomes of the first confirmed cases of COVID-19 infection (n=127).Materials and Methods: This prospective study was conducted on all COVID-19-suspected cases, admitted to Masih Daneshvari Hospital (a designated hospital for COVID-19), Tehran, Iran, since February 19, 2020. All patients were tested for COVID-19, using reverse transcription-polymerase chain reaction (RT-PCR) assay. Data of confirmed cases, including demographic characteristics, clinical features, and outcomes, were collected and compared between three groups of patients, requiring different types of admission (requiring ICU admission, admission to the general ward, and transfer to ICU).Results: Of 412 suspected cases, with the mean age of 54.1 years (SD=13.4), 127 (31%) were positive for COVID-19. Following the patients’ first visit to the clinic, 115 cases were admitted to the general ward, while ten patients required ICU admission. Due to clinical deterioration in the condition of 25 patients (out of 115 patients), ICU admission was essential. Based on the results, the baseline characteristics of the groups were similar. Patients requiring ICU admission were more likely to have multiorgan involvement (liver involvement, p <0.001; renal involvement, p <0.001; and cardiac involvement, P=0.02), low O2 saturation (p <0.001), and lymphopenia (P=0.05). During hospital admission, 21 (16.5%) patients died, while the rest (83.5%) were discharged and followed-up until March 26, 2020. Also, the survival rate of patients, who received immunoglobulin, was higher than other patients (60.87% vs. 39.13%).Conclusion: The mortality rate of COVID-19 patients was considerable in our study. Based on the present results, this infection can cause multiorgan damage. Therefore, intensive monitoring of these patients needs to be considered.
COVID-19
Features
ICU
outcomes
2020
04
01
122
128
https://www.tanaffosjournal.ir/article_239712_360c42ba6541af7b936e9410077c5521.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Effect of Head Position Change on Endotracheal Cuff Pressure in Mechanically Ventilated Patients: A Quasi-Experimental Study
Roghieh
Nazari
Mohammad
Salehpour Omran
Hamid
Sharif Nia
Ameneh
Yaghoobzadeh
Background: Endotracheal cuff pressure may be affected by various factors and interventions. Therefore, this study was conducted to investigate the effect of head position change on cuff pressure of the endotracheal tube whilst undergoing mechanical ventilation.Materials and Methods: In this semi-experimental study, 61 intubated patients undergoing mechanical ventilation were studied. Each subject was used as their own control group. First, each patient was placed in starting position and the cuff pressure was adjusted in the range of 20-30 cmH2O. Then, the head position was placed in anterior flexion, hyperextension, left lateral flexion, right lateral flexion, left rotation, and right rotation without separating the manometer from the pilot cuff. The cuff pressure was recorded and analyzed at each stage.Results: The endotracheal cuff pressure increased in all six head positions. The highest difference in pressure was observed in the anterior flexion and left rotation positions (p <0.001). The observed increases in cuff pressure were higher than the normal range (30 cmH2O) in a significant number of patients.Conclusion: Changing the head position in mechanically ventilated patients increases endotracheal cuff pressure. Therefore, it is suggested that the cuff pressure should be re-examined and adjusted after each head position change while avoiding unnecessary movements of the head and neck of the intubated patients.
Endotracheal Intubation
Cuff pressure
Head position
Intensive care unit
2020
04
01
129
134
https://www.tanaffosjournal.ir/article_239713_300dad0c127fbbee811bfa9d4418f3df.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
The Association of Sleep Duration and Quality with Heart Rate Variability and Blood Pressure
Amirreza
Sajjadieh
Ali
Shahsavari
Ali
Safae
Thomas
Penzel
Christoph
Schoebel
Ingo
Fietze
Nafiseh
Mozafarian
Babak
Amra
Roya
Kelishadi
Background: The current study was conducted to evaluate the relation of sleep duration and quality with blood pressure (BP) and heart rate variability (HRV). Materials and Methods: This cross-sectional study was carried out in 2017 among 260 staff of a university hospital in Isfahan, Iran. They were selected by multi-stage random method from different wards. Time domain spectral analysis was used to measure a number of HRV parameters. The long-term components of the HRV were estimated using the standard deviation of the normal-to-normal interval (SDNN). The square root of the mean squared differences of successive NN intervals (RMSSD) was calculated by statistical time domain measurements; SNN50, and PNN50 were measured. Pittsburg sleep quality index (PSQI) questionnaire was used to assess sleep quality. Results: Higher PSQI score correlated with lower SDANN rise (OR=0.92). Fairly bad to very good subjective sleep quality had association with lower SDANN (OR=0.43). Very high sleep latency to very low sleep latency ratio had association with lower SDANN (OR=0.39) and lower PNN50 (OR= 0.44). Sleep duration and HRV parameters had no significant association. Fairly bad sleep efficiency to very good sleep efficiency ratio was correlated with lower SDANN (OR= 0.29). Very high daytime dysfunction to very low daytime dysfunction ratio had correlation with lower SDANN (OR=0.35). Very bad compared to very good subjective sleep quality had significant correlation with higher Heart rate (HR) (B=0.03). Very high sleep latency compared to no sleep latency was associated with higher HR (B=4.74). Very high compared to very low amount of sleep disturbances correlated with higher SBP levels (B=15.2). Using sleep medication less than once a week compared with no history of taking such drugs was associated with higher HR (B=16.4). Conclusion: Our findings showed that poor sleep quality are adversely associated with HRV, HR and BP. This finding should be considered in clinical and preventive recommendations.
Sleep duration
sleep quality
Heart rate variability
Blood pressure
2020
04
01
135
143
https://www.tanaffosjournal.ir/article_242146_050977fd76f7a68418a04c8e6583c537.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Relationship between Pulmonary Function Tests and Severity of Coronary Artery Disease in Patients with Chronic Obstructive Pulmonary Disease
Arsalan
Salari
Fardin
Mirbolouk
Asiyeh
Ashouri
Pedram
Salari
Hanie
Shadrou
Zahra
Mehdipour
Mahboobeh
Gholipour
Background: The aim of this study was to examine relationship between the parameters of pulmonary function and the severity of coronary artery disease (CAD) in chronic obstructive lung disease patients. Materials and Methods: Four hundred and twenty four patients with ischemic heart diseases who underwent coronary angiography were studied. The demographic characteristics and medical history of the patients were obtained from their medical records.The severity of COPD was determined according to the Global Initiative for Chronic Obstructive Lung Disease. In addition, the severity of CAD was quantified by SYNTAX scoring . Results: Eighty-eight (21.2%), 270 (65.1%), 52 (12.5%), and 5 (1.2%) of the patients had the grade 1, 2, 3, or 4 COPD, respectively. In addition, 46 (11.1%), 319 (76.9%), and 50 (12.0%) of them had low, intermediate, and high CAD, respectively. A statistically significant relationship was observed between the severity of COPD and the severity of CAD. Significant relationships were found between age, sex, BMI, LDL, EF, and systolic pressure of pulmonary artery with the severity of COPD. The odds of higher CAD in females were 1.849 times higher than male patients. In addition, the odds of high CAD in the patients with grade 1 or 2 COPD were 0.006 and 0.068 times of the patients with grades 3 and 4 COPD, respectively . Conclusions: The findings of the present study indicate that the parameters of pulmonary function and the severity of CAD are associated with the severity of COPD.
coronary artery disease
COPD
Pulmonary function test
SYNTAX score
2020
04
01
144
151
https://www.tanaffosjournal.ir/article_242147_2323c3bf53fe72f15e538bd6998ca4cd.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Prone-Position Ventilation in a Pregnant Woman with Severe COVID-19 Infection Associated with Acute Respiratory Distress Syndrome
Guitti
Pourdowlat
Amir
Mikaeilvand
Mitra
Eftekhariyazdi
Mohammad
Nematshahi
Masoud
Ebrahimi
Asghar
Kazemzadeh
A 25-year-old pregnant woman (gestational age: 24 weeks) presented with severe coronavirus disease-2019 (COVID-19) infection. Deterioration of her respiratory status resulted in her admission to the intensive care unit and mechanical ventilator support. Considering the lack of improvement in oxygen saturation, teleconsultation was performed, suggesting prone-position ventilation (PPV). Significant improvements were observed in oxygen saturation. The patient was extubated after five days of intermittent PPV and supine-position ventilation and was discharged 20 days after admission. Also, assessments revealed that the fetus was unharmed by the intervention. We suggest considering PPV for pregnant women with acute respiratory distress syndrome (ARDS).
COVID-19
Prone-position ventilation
Pregnancy
Acute respiratory distress syndrome
2020
04
01
152
155
https://www.tanaffosjournal.ir/article_242148_a709b1124f8f92099cbd0d8a8bc68375.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
The First Confirmed Case of Coronavirus Disease 2019 (COVID-19) in an Adolescent with Abdominal Pain in Iran
Shima
Mahmoudi
Maryam
Rostamyan
Alireza
Aziz-Ahari
Babak
Pourakbari
Mohammad
Ghaffari
Setareh
Mamishi
Background: The outbreak of coronavirus disease 2019 (COVID-19) is evolving rapidly. However, there is limited information about this disease in children and adolescents. Only a few pediatric cases of COVID-19 have been reported so far. Since the immune responses of children are different from adults, their clinical findings and therapeutic responses may differ. To the best of our knowledge, this is the first confirmed case of COVID-19 in a 12-year-old girl with abdominal pain in Iran. Case Presentation: A 12-year-old girl with a history of cold, dry cough, sore throat, fever, and left-sided abdominal pain was referred to the Children’s Medical Center, Tehran, Iran, on March 7, 2020. The chest X-ray indicated air space opacification in the right lower lobe and faint ground-glass opacity in the left lower lung. A subsequent chest computed tomography (CT) scan indicated blialteral patchy lower lobe consolidations. The patient’s oropharyngeal swab was positive for COVID-19, based on the result of real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay. The patient’s clinical status was improved, and she was discharged five days after admission (March 11, 2020). Conclusion: Since the number of infected cases with COVID-19 is growing rapidly in Iran, early detection and management of infected cases are highly recommended for preventing the disease transmission and reducing the rate of infection.
COVID-19
Children
Iran
2020
04
01
156
159
https://www.tanaffosjournal.ir/article_242149_054cd9bb2ffdb31b063a6c8c2b850f5e.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Neurological Manifestations of COVID-19: A Case Report
Majid
Malekmohammad
Seyed Mohammad Reza
Hashemian
Babak
Mansourafshar
Hamidreza
Jamaati
A novel coronavirus disease (COVID-19) was reported in Wuhan, China in December 2019 and spread rapidly around the world, causing high rates of mortality and morbidity. This disease is known for its respiratory manifestations. Also, there have been several reports of neurological involvement in patients with COVID-19. In this study, we present a 55-year-old Iranian male patient, who was referred from another medical center with a decreased level of consciousness. Upon admission, only respiratory signs of COVID-19 were observed, but later, some neurological manifestations were also observed, such as an alteration in mental status, disorientation, stupor, and finally coma. In radiological studies, a hemorrhagic encephalopathy pattern was detected. Despite improved oxygenation and alleviation of respiratory symptoms with antiviral and anti-inflammatory therapies, cerebral injuries progressed, and the patient died due to severe brain damage.
COVID-19 encephalopathy
Central nervous system
Ischemia
2020
04
01
160
164
https://www.tanaffosjournal.ir/article_242150_aac51a3103cac8d33a5f1d373ef939e1.pdf
TANAFFOS (Respiration)
1735-0344
1735-0344
2020
19
2
Transhiatal Esophagectomy after Previous Left Pneumonectomy: Challenge of Surgical Approach, a Case Report
Abdoulhossein
Davoodabadi
Mohammad Ali
Saba
Abbas
Arj
Hamidreza
Talari
The occurrence of esophageal cancer after previous pneumonectomy for primary lung cancer is rare. This is the second case report of transhiatal esophagectomy after previous pneumonectomy due to lung cancer. In this case, selection of surgical approach for esophagectomy, was technically challenging and anatomic deformity in post pneumonectomy space had potential risk of physiologic disturbance, especially after thoracotomy option in solitary lung with limited capacity. Case presentation: We herein report a 58 year old man with history of left pneumonectomy and lymph node dissection due to mucoepidermoid carcinoma 19 years ago and recently admitted for esophageal carcinoma. He successfully was managed via transhiatal approach. Conclusion: Transhiatal esophagectomy in pneuminectomized patient is safe and recommended as first option.
Esophageal cancer
Lung cancer
Pneumonectomy
Transhiatal esophagectomy
2020
04
01
165
169
https://www.tanaffosjournal.ir/article_242151_7d652bde01005e80c9ecedbbf80433ce.pdf