TY - JOUR ID - 254225 TI - Assessment of Cystic Fibrosis Distribution Based on Air Pollution by Geographical Information System (GIS) JO - TANAFFOS (Respiration) JA - RSPR LA - en SN - 1735-0344 AU - Hassanzad, Maryam AU - Farnia, Parissa AU - Farnia, Poopak AU - Arian, Mahdieh AU - Valinejadi, Ali AU - Ghaffaripour, Hosseinali AU - Baghaie, Noushin AU - Hassanzad, Nima AU - Mohammadpour, Leila AU - Velayati, Ali Akbar AD - Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Mycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Ira AD - Department of Health Information Technology, School of Allied Medical Sciences, Semnan University of Medical Sciences, Semnan, Iran AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Y1 - 2022 PY - 2022 VL - 21 IS - 1 SP - 31 EP - 44 KW - Climatic processes KW - Cystic Fibrosis KW - Disease mapping KW - Geographic Information System KW - Medical informatics DO - N2 - Background: It is widely accepted that concerns have been recently raised regarding the impact of air pollution on the health of children with cystic fibrosis (CF). Air pollution probably affects the exacerbation of CF and its laboratory findings. On the other hand, the World Health Organization (WHO) has asked all countries to update their data and reports on the distribution and prevalence of CF in different areas. The purpose of the present study was to investigate the distribution and prevalence of CF based on the levels of atmospheric pollutants, such as PM10, PM2.5, SO2, NO2, CO, and O3 in 22 zones of Tehran, and to report the abnormal laboratory findings that might indicate the exacerbation of CF. Materials and Methods: The studied statistical population included children with CF referred to Masih Daneshvari Hospital from 2003 to 2020. Demographic data, location of living area, and laboratory findings were extracted from patient records. The geographic information system (GIS) was applied to indicate the distribution and dispersion of the disease. The information related to air pollutants was collected from all stations in Tehran during the studied period by the Department of Environment of Tehran Province, and the average levels were used for final reporting. Results: The analysis results on 287 CF patients demonstrated that the risk of disease exacerbation significantly increased by the presence of air pollutants. In areas with multiple air pollutants, more laboratory findings were observed to be abnormal, and the lower survival rate for patients with CF was recorded. Investigating the CF distribution pattern based on climatic layers and above mean sea level (AMSL) indicated that distribution of the disease was higher in dry areas with lower AMSL and the higher volume of the atmospheric pollutants, which were primarily centralized in southern and central Tehran. Conclusion: Environmental factors, such as air pollution, can be considered vital parameters, along with high-risk factors, such as pure and integrated race, migration, and mutation, influencing the prevalence and exacerbation of CF symptoms. Considering the higher prevalence of CF in deprived areas of Tehran, households' cultural and economic level appears to be a factor in the lack of diagnostic screening and prevention of CF in these areas. On the other hand, continuous monitoring of the air pollution caused by traffic and giving warnings to CF patients and their parents is particularly important. UR - https://www.tanaffosjournal.ir/article_254225.html L1 - https://www.tanaffosjournal.ir/article_254225_215336d489c873c58db78d10da970fa8.pdf ER -