TY - JOUR ID - 240241 TI - Prevalence of HLA-B*5701 and Its Relationship with Abacavir Hypersensitivity Reaction in Iranian HIV- Infected Patients JO - TANAFFOS (Respiration) JA - RSPR LA - en SN - 1735-0344 AU - Baniasadi, Shadi AU - Baradaran Shokouhi, Shokoufeh AU - Tabarsi, Payam AU - Alehashem, Maryam AU - Khalili, Hossein AU - Fahimi, Fanak AU - Alireza Nadji, Seyed AD - Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran, AD - Virology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran, AD - Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran, AD - Clinical Pharmacy Department, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran, AD - Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Y1 - 2016 PY - 2016 VL - 15 IS - 1 SP - 48 EP - 52 KW - Abacavir KW - Antiretroviral therapy KW - HIV KW - HLA-B*5701 allele KW - Hypersensitivity reaction KW - Iran DO - N2 - Background: Hypersensitivity reaction (HSR) is a major adverse effect of abacavir (ABC), which occurs in 5-8% of Caucasians. The relationship between Human Leukocyte Antigen (HLA) and ABC HSR has been reported in various populations. It has been proposed to administer ABC only to HLA-B*5701 negative patients to avoid this reaction. The purpose of this study was to assess the prevalence of HLA-B*5701 in Iranian HIV positive patients. We also sought to find the relationship between this allele with ABC HSR in patients who received the medication. Materials and Methods: We screened patients for HLA-B*5701 allele using SybrGreen real time PCR-melting method on blood samples from HIV positive patients who were referred to our hospital. The quality of the extracted genome was evaluated by B-globin housekeeping gene as internal control prior to HLAB*5701 allele screening. Results: Of 198 HIV-infected patients, 6 (3.0%) had the HLA-B*5701 allele (95% CI, 1%–5%). Among the 28 patients who were given ABC, one individual had the HLA-B*5701 allele and experienced ABC HSR. Conclusion: Prevalence of HLA-B*5701 in Iranian patients was lower than that in Caucasians but was comparable with that of other Middle Eastern populations. Screening for HLA-B*5701 before ABC administration as part of antiretroviral therapy may reduce the risk of HSR.   UR - https://www.tanaffosjournal.ir/article_240241.html L1 - https://www.tanaffosjournal.ir/article_240241_7b71b2829b03cb8a3a1fe70dfb885f38.pdf ER -