TY - JOUR ID - 240054 TI - Effect of Diaphragm Plication in Thymoma Patients with and without Myasthenia Gravis JO - TANAFFOS (Respiration) JA - RSPR LA - en SN - 1735-0344 AU - Bagheri, Reza AU - Ziaollah Haghi, Seyed AU - Afghani, Reza AU - Azmounfar, Vahab AU - Hakimian, Saeed AU - Baradaran Firoozabad, Mohammad AU - Morovatdar, Negar AU - Lotfian, Elham AD - Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of General Surgery, 5th of Azar Hospital, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran, AD - Student Research Committee, Mashhad University of Medical science, Mashhad, Iran, AD - Mashhad University of Medical Science, Mashhad, Iran, AD - Imam Reza Clinical Research Unit, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Y1 - 2018 PY - 2018 VL - 17 IS - 3 SP - 177 EP - 182 KW - Plication KW - Diaphragm KW - Phrenic nerve KW - Thymoma KW - Myasthenia gravis DO - N2 - Background: Thymoma is the most common tumor of the anterior mediastinum that has the most effective treatment, as it can be completely resected. In patients with advanced stage, phrenic nerve involvement can be seen and suggested treatment for these patients is unilateral phrenic excision and diaphragm plication. However in patients with myasthenia gravis, there are concerns in relation to this method of treatment. The aim of this study is to evaluate the effects of plication of the diaphragm on complications of phrenic nerve excision in thymoma patients with and without myasthenia gravis involving the phrenic nerve. Materials and Methods: A retrospective cohort study was performed on 26 patients with thymoma; half of the patients had myasthenia gravis and the other half did not have myasthenia gravis. We performed diaphragm plication in 7 patients in each group with excision of phrenic nerve. Patients were evaluated based on preoperative and postoperative variables. Results: The patients’ age (P=0.943), sex (P=0.999), blood loss during surgery (P=0.919), need for transfusion during surgery (P=0.999), short term complications (P=0.186), need for tracheostomy (P=0.27) and mortality (P=0.09) differences were not significant. However, the average duration of ICU stay (P=0.001) and intubation in ICU (P=0.001) in patients who had myasthenia gravis was more than patients without myasthenia gravis. These values were less in patients with myasthenia gravis and diaphragm plication than patients with myasthenia gravis and no diaphragm plication. Conclusion: Excision of the phrenic nerve in patients with myasthenia gravis associated with thymoma and phrenic nerve involvement is appropriate. UR - https://www.tanaffosjournal.ir/article_240054.html L1 - https://www.tanaffosjournal.ir/article_240054_a22818ed4b006a85565164939dfd6277.pdf ER -