National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Identification of Novel Therapeutic Targets in COPD
9
14
EN
Esmaeil
Mortaz
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99,
Utrecht, The Netherlands
Mohammad Reza
Masjedi
Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung
Disease (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Peter
Barnes
Cell and Molecular
Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, UK
https://www.tanaffosjournal.ir/article_241116.html
https://www.tanaffosjournal.ir/article_241116_cf1566da04005c193ea12764280f1ae1.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Clinical and Demographic Characteristics of Confirmed Cases in H1N1 (2009) Influenza
15
19
EN
Ahmadreza
Moradi
Virology Research Center
Afsaneh
Sigaroodi
Virology Research Center
Leila
Poosh-Ashkan
Virology Research Center
Seyed Alireza
Nadji
Virology Research Center
Payam
Tabarsi
Mycobacteriology Research Center
Seyed Davood
Mansouri
Clinical Tuberculosis and Epidemiology Research Center
Mohammadreza
Masjedi
Chronic
Respiratory Disease Research Center
Ali Akbar
Velayati
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid
Beheshti University of Medical Sciences, Tehran- Iran.
Background: Presentation of pandemic H1N1 influenza (H1N1) is widely evolving as it continues to involve different geographic locations and populations. This study was conducted to improve the precision of clinical diagnosis of H1N1 (2009) influenza infection in an outpatient setting. Materials and Methods: A prospective cross-sectional study was conducted among adult patients (age >15 years) with influenza-like illnesses (ILI) from November 2009 to February 2010. Clinical, laboratory and epidemiological findings in the first week of illness were collected using a standardized datasheet. Influenza testing was performed by real-time reversetranscriptase polymerase chain reaction (rRT-PCR). Results: Thirty nine (24%) patients were positive for H1N1 and 123 (76%) were negative for any subtype of influenza A virus. Whilst otalgia (14% vs. 0 p= 0.01) was more prevalent in non-influenza A cases, cough (90% vs. 72% p = 0.03) and shortness of breath (67% vs. 47% p = 0.02) were more often associated with H1N1-infection. Comparative analysis of coexisting conditions and demographic factors of patients revealed no other significant differences between the two groups. Conclusion: The clinical presentation of H1N1 (2009) infection is largely indistinguishable from other acute respiratory diseases. Although previous studies suggested significant differences in demographic and co-existing conditions of H1N1 infected patients, our study shows that as the pandemic spreads worldwide and affects the majority of the population, H1N1 diagnosis based on clinical presentation and demographic characteristics has become less practical and much more difficult in tertiary care centers. (Tanaffos2011; 10(2): 15-19)
H1N1 Influenza,Pandemic,Demographic Data
https://www.tanaffosjournal.ir/article_241117.html
https://www.tanaffosjournal.ir/article_241117_86f5731eeb9ffe0b8026e335d561eb7e.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Effect of Fluid Balance on Alveolar-Arterial Oxygen Gradient in Mechanically Ventilated Patients
20
24
EN
Masoud
Aliyali
Internal Medicine Department, Pulmonary and Critical Care Division, Mazandaran University of Medical Sciences, Sari-Iran
Ali
Sharifpour
Internal Medicine Department, Pulmonary and Critical Care Division, Mazandaran University of Medical Sciences, Sari-Iran
Abdolrasol
Tavakoli
Internal Medicine Department, Pulmonary and Critical Care Division, Mazandaran University of Medical Sciences, Sari-Iran
Background: Fluid balance affects outcome in critically ill patients. We studied the effect of fluid balance on oxygen exchange by assessing alveolar-arterial oxygen gradient (PA-a O2) in mechanically ventilated patients. Our primary objective was to evaluate the difference in PA-aO2 and the secondary goal was to evaluate the differences in age and mortality rate. Materials and Methods: This retrospective observational study was performed on patients who were admitted to medical and surgical ICUs of Sari Imam Hospital, Mazandaran University of Medical Sciences, from 2003 to 2009. Daily fluid balance was calculated by input minus output. Thirty patients with continuous positive fluid balance (PFB) and 30 subjects with continuous negative fluid balance (NFB) during 4 consecutive days were enrolled in this study. PA-a O2 was calculated in these two groups. Results: The mean (±SD) age was 48.9±21.2 yrs. in PFB group (19 males and 11 females) and 37.1±15.7 yrs. in NFB group (25 males and 5 females) which showed a statistically significant difference in age between the two groups (p=0.017). The 24h, 48h, and 96h fluid balances were 1226cc±881, 1311cc±751, and 957cc±661 in PFB group and -1122cc±692, -920cc±394, and -1164cc±695 in NFB group, respectively. The mean differences (±SD) of PA-a O2 in 24h, 48h, and 96h versus the same value in the admission day were 11.3±39.2, 1.69±51.1, and -1.50±64 in PFB subjects and -21.8±60.8, -27.8±84.9, and - 19.3±68.7 in NFB patients. The difference was statistically significant only in the first day of admission (p=0.015). However, no difference was detected in overall mean oxygen gradient during 96h among the two groups. Mortality rate was significantly higher in PFB patients (p <0.0001). Conclusion: Positive fluid balance had no significant effect on PA-a O2 but can be used as a predictor of mortality. (Tanaffos 2011; 10(2): 20-24)
Fluid balance,Alveolar-arterial oxygen gradient,PA-a O2,Mechanical ventilation
https://www.tanaffosjournal.ir/article_241118.html
https://www.tanaffosjournal.ir/article_241118_1202b4749e4208121802233a0119b402.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Clonality of the Immunoglobulin Heavy Chain Genes in B Cell Non-Hodgkin Lymphoma Using Semi-Nested PCR
25
31
EN
Zohreh Mohammad
Taheri
Virology Research Center,
Leila Mohammadi
Ziazi
Department of Pathology
Atosa
Dorudinia
Department of Pathology
Seyed Alireza
Nadji
Virology Research Center
Forozan
Mohammadi
Department of Pathology
Background: Identification of gene rearrangements and clonality analysis are important techniques for the diagnosis of malignant lymphoproliferative diseases. These methods have various sensitivities based on the type of primer used and method of determination of polymerase chain reaction (PCR) products. This study aimed at determining the clonality of B cell non-Hodgkin lymphoma in Iranian patients using PCR method and 2 primers of FR2 and FR3. Materials and Methods: Paraffin embedded blocks of 67 patients with B cell lymphoma and 19 cases with lymphoid hyperplasia of the lymph nodes who presented to NRITLD, Masih Daneshvari Hospital were retrospectively reviewed. After extracting the genomic DNA using phenol and chloroform, clonal analysis was performed using semi-nested PCR by using two primers: FR2 and FR3. PCR products were determined using 2 techniques of heteroduplex analysis, polyacrylamide gel and silver staining and the conventional method of agarose gel and ethidium bromide staining. Appearance of 1 or 2 bands in the desired location were considered as a sign of clonality. Results: Monoclonal gene rearrangement was observed in 62 out of 67 patients (92.5%) as one or two discrete bands appeared within 60- 120 base pairs (bp) and 200-300 bp range. Of the mentioned patients, 53 cases (79.1%) had FR2 and 51 (76.1%) had FR3 rearrangement. Heteroduplex analysis along with silver nitrate staining detected 3 out of the remaining 5 cases of lymphoma to be monoclonal. These cases had been reported negative by the conventional technique. In total, 65 out of 67 patients (97%) showed monoclonal gene rearrangement using both the abovementioned techniques. All hyperplasia cases were polyclonal by this method. Conclusion: Our study showed that evaluation and detection of clonality using PCR, FR2 and FR3 primers along with heteroduplex analysis is a rapid sensitive technique for the diagnosis of malignant lymphomas. (Tanaffos2011; 10(2): 25-31)
Clonality,B cell non-Hodgkin lymphoma,Polymerase chain reaction (PCR)
https://www.tanaffosjournal.ir/article_241119.html
https://www.tanaffosjournal.ir/article_241119_656c469c5ec9f6b5a0d8515a22961866.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Maternal Nicotine Induces Collagen Type IV Changes in the Mice Lung Parenchyma and its Vessels
32
37
EN
Shabnam
Mohammadi
Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Reza
Nikravesh
Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mehdi
Jalali
Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abbas Ali
Moeen
Department of Anatomy,
School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Mohammad Hassan
Karimfar
3 Department of Anatomy, School of Medicine, Ilam University of
Medical Sciences, Ilam- Iran.
Background: One of the undesirable effects of maternal nicotine exposure during pregnancy is pulmonary hypertension. Since nicotine binds to its receptors on pulmonary vessels the hypothesis of this research was the possible structural changes that nicotine may cause on newborn vessels. Materials and Methods: Twenty-four female BALB/c mice were mated and finding vaginal plug was assumed as day zero of pregnancy. Pregnant mice were divided into 2 experimental and 2 control groups. Experimental group 1 received 3 mg/kg nicotine intraperitoneally from day 5 of gestation until the last day of pregnancy. Experimental group 2 received the same amount of nicotine during the same gestational days as well as the first 2 weeks after birth (lactation). The control groups received the same volume of normal saline during the same periods. At the end of exposure times, all the newborns (experimental and control) were anesthetized, their lungs were removed and immunohistochemical studies were carried out for tracing collagen. Results: Our findings indicated that collagen reaction in the bronchial basement membrane (BBM) and extracellular matrix (ECM) of the lung parenchyma in experimental groups increased significantly compared to the control groups but these changes were not observed in BM of lung vessels in the experimental groups. Conclusion: These data indicate that nicotine exposure during pregnancy does not cause a significant change in collagen type IV in BM of lung vessels. But this does not mean that other types of collagen fibers do not indicate change because the wall thickness of pulmonary vessels in experimental groups increased significantly compared to the control groups. (Tanaffos2011; 10(2): 32-37)
Nicotine,Collagen type IV,Lung vessels,Mouse
https://www.tanaffosjournal.ir/article_241120.html
https://www.tanaffosjournal.ir/article_241120_3fdc223bf56490d3a082cacd3d529e07.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Primary Immunodeficiency in Children: Report of Seven Years Study
38
43
EN
Soheila
Khalilzadeh
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,
Tehran- Iran.
Mohammad Reza
Boloorsaz
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,
Tehran- Iran.
Nooshin
Baghaie
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,
Tehran- Iran.
Sajedeh Mir Mohammad
Sadeghi
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,
Tehran- Iran.
Maryam
Hassanzad
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,
Tehran- Iran.
Ali Akbar
Velayati
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,
Tehran- Iran.
Background: Primary immunodeficiency diseases (PIDs) are a genetically heterogeneous group of disorders that affect distinct components of the innate and adaptive immune system, such as neutrophils, macrophages, dendritic cells, complement proteins, natural killer cells, T and B lymphocytes. These disorders are rare, with an estimated prevalence of 1:10,000 live births. Objectives: This study aimed at describing the clinical features, disease complications, treatment modalities and overall outcome of patients with Primary Immunodeficiency Diseases (PID) in Masih Daneshvari hospital during a 7-year period (2001-2008). Materials and Methods: This was a retrospective study based on the review of patients’ medical records. Clinical, laboratory, and epidemiological data including personal and family history were obtained by reviewing records of patients admitted to the Pediatric Pulmonary Ward of NRITLD, a referral center for tuberculosis and lung diseases. The diagnosis was made based on WHO criteria for primary immunodeficiency disorders. Results: Data collected from 59 patients were evaluated and analyzed. There were 35 (59.3%) males and 24 (40.69%) females. The age of patients ranged from 6 months to 14.5 years and the mean age was 7.4 years. Positive family history was detected in 20 (33.9%) cases and parents of 36 patients (61.2%) were consanguineous. Twenty patients (33.9%) had a family history of PID. Phagocytic disorder (57.2%) was the most common form of PID, followed by antibody deficiency (33.7%) and T-cell or combined deficiency (8.2%). No case of complement deficiency was detected. In this group of under study patients, 2 cases expired as the result of respiratory failure due to drug resistant pneumonia (chronic granulomatous disease cases). Conclusion: Based on studied results, Phagocytic disorders (57.2%) were the most common disorders among our PID patients. This may be due to the large number of CGD patients referred with the pathologic finding of granuloma misdiagnosed with tuberculosis. Considering the high prevalence of PID in this study, cases with unusual, chronic, severe or recurrent infections should be evaluated for immunodeficiency disorders. (Tanaffos2011; 10(2): 38-43)
https://www.tanaffosjournal.ir/article_241121.html
https://www.tanaffosjournal.ir/article_241121_78625477979a23096a998f3eb9d0540c.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Respiratory Findings in Dental Laboratory Technicians in Rasht (North of Iran)
44
49
EN
Ali
Alavi
Respiratory Diseases and TB Research Center, Guilan University of Medical Sciences (GUMS), Razi Hospital, Rasht- Iran.
Maryam
Shakiba
Respiratory Diseases and TB Research Center, Guilan University of Medical Sciences (GUMS), Razi Hospital, Rasht- Iran.
Azita
Tangestani Nejad
Respiratory Diseases and TB Research Center, Guilan University of Medical Sciences (GUMS), Razi Hospital, Rasht- Iran.
Sara
Massahnia
Respiratory Diseases and TB Research Center, Guilan University of Medical Sciences (GUMS), Razi Hospital, Rasht- Iran.
Ali
Shiari
Respiratory Diseases and TB Research Center, Guilan University of Medical Sciences (GUMS), Razi Hospital, Rasht- Iran.
Background: There are several occupations that can expose people to some air pollutants. Dental technicians are exposed to inorganic dust and chemical vapors when making dental prosthesis that can put them at risk for respiratory problems. This study was performed to assess respiratory dysfunction in a group of dental technicians. Materials and Methods: This was a cross-sectional study designed to ascertain the prevalence of respiratory disorders in dental laboratory technicians in Rasht, a city located in north of Iran. A Structured questionnaire was adapted according to the European Community Respiratory Health Survey questionnaire and used to elicit information regarding sociodemographic characteristics and medical status of the study participants. The ventilation status, protective measures and direct exposure to materials in the laboratories were directly observed by the observers and subjects underwent respiratory tests and chest x-ray. Results: The mean age of dental technicians was 31.31 yrs (range 18-56 years) and 83% were males with a mean dental work experience of 9.04 years. In 54.8% of cases, the work environment did not have air conditioning system. The most common signs and symptoms were cough (38.1%) and wheezing (16.7%).There was a significant correlation between smoking and respiratory signs. Restrictive airway pattern and air trapping were two prevalent findings which were observed in 85.7% and 33.3% of the subjects. Cigarette smoking had a negative effect on FEV1, FEF25%-75%, and TLC causing a significant reduction in all three parameters (p <0.05). The most prevalent finding was interstitial opacity which was observed in 10 individuals (23.8%).This finding was not significantly associated with age, gender, cigarette smoking, or daily work hours. However, there was a significant statistical association between work experience and interstitial opacity. Conclusion: The prevalence of respiratory dysfunction and chest x-ray findings were high as in several similar studies. In order to reduce the hazards of respiratory disorders in risky occupations and provide dental workers with technical preventive measures, a more comprehensive study should be conducted throughout the country and further evaluations through biopsy and CT-scan need to be performed in suspicious cases when necessary. (Tanaffos2011; 10(2): 44-49)
Dental technicians,Respiratory disorders,Respiratory function test
https://www.tanaffosjournal.ir/article_241122.html
https://www.tanaffosjournal.ir/article_241122_704b28f07c9f45137c3fc55d9f6e7609.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Pattern of Tobacco Consumption among TB Patients in a Tuberculosis Referral Center
50
55
EN
Mitra
Safa
Clinical Tuberculois and Epidemiology Research Center
Payam
Tabarsi
Mycobacteriology Research Center
Hooman
Sharifi
Tobacco Prevention and Control
Research Center, NRITLD,Shahid Beheshti University of Medical Sciecnes, Tehran- Iran
Background: Tuberculosis (TB) is among the major causes of illness and death worldwide, especially in Asia and Africa. On the other hand, tobacco use is the most important preventable and the second biggest cause of death throughout the world. Smoking is associated with recurrent tuberculosis and its related mortality. Also, it could affect clinical manifestations, bacteriological conversion and outcome of treatment. This study aimed to evaluate the pattern of tobacco smoking, history of previous quit attempts, and attitude towards quitting in tuberculosis patients. Materials and Methods: It was a cross-sectional study done amongst pulmonary TB patients presented to Masih Daneshvari Hospital. Two hundred patients entered the study as "First Come First Serve". Self-reported questionnaires were designed according to the standard questionnaires of smoking pattern. Results: A total of 93.5% were males. The mean age was 39.8±1.73 yrs. Thirty-four percent of them were current smokers at the time of interview, 7.5% were occasional smokers and 28% of smoker patients had a history of at least one quit attempt. Conclusion: Considering the prevalence of smoking in TB patients, evaluation of tobacco smoking status in such patients and motivating them to quit smoking could be considered as important steps in their treatment process. (Tanaffos2011; 10(2): 50-55)
tuberculosis,Smoking Cessation,Tobacco,Smoking
https://www.tanaffosjournal.ir/article_241124.html
https://www.tanaffosjournal.ir/article_241124_e83e530807e6bc5f792605a39e44171d.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Novel Technique for Placement of Laryngeal Mask Airway in Difficult Pediatric Airways
56
68
EN
Fatemeh
Roodneshin
Department of Anesthesiology and Intensive Care, Labaffinejad Hospital,
Mahvash
Agah
Anesthesiology Research Center, Shahid Beheshti University of Medical
Sciences, Tehran-Iran.
Background: The main responsibility of an anesthesiologist is to safely maintain an open airway and preserve sufficient gas exchange in the lungs. This role becomes more significant when managing children especially those with difficult airways (DA). In such cases, a quick appropriate action can decrease the related mortality and morbidity. Laryngeal mask airway (LMA) is a device used in cases with difficult airways. Its placement is much more difficult in children especially those with DA. There is a greater risk of malpositioning and its insertion with routine techniques is sometimes impossible. In this article, we introduce a new method for replacement of LMA in difficult pediatric airways (DPA). Materials and Methods: In this before and after, pre and post design clinical trial, we evaluated 30 children with congenital anomalies and difficult airways who were candidates for elective eye surgery (short term). A written consent was obtained from the parents or the legal guardians of those who met the inclusion criteria. Inhalation anesthesia was induced by sevoflurane. The patients had assisted spontaneous respiration. No muscle relaxant was administered. LMA was inserted using the classic method in the anesthesia depth of BIS=35-40. After 2 unsuccessful attempts according to the criteria for adequate function of LMA, we tried placing the LMA using our innovated method after meeting the primary requirements and reaching the anesthesia depth of 35-40. In this method, the index finger of the left hand was placed on the tongue pushing it downwards (towards the floor of the mouth) when inserting the LMA. This way, we assisted LMA passing down the pharynx resulting in its adequate positioning. Criteria for adequate function of LMA in both classic and innovated insertion methods included monitoring of easy ventilation, no resistance during exhalation, adequate chest movement, no air leakage, optimal airway pressure, optimal lung compliance, level of oxygenation of arterial blood and level of CO2 at the end of exhalation. In case of presence of air leakage with bag pressure below 15 cm of water, lack of chest movement during inhalation, upper airway pressure over 20 cm of water, SPO2 lower than 90% and low compliance of the lung, LMA placement would be considered a failure. In such cases, LMA would be immediately extracted and the required depth of anesthesia would be reached using an oxygen mask and required inhalations. Complications occurring during the procedure and after LMA extraction would be recorded. Results: Our understudy population included 30 children in the age range of 1.5 months to 10 yrs (11 girls and 19 boys) who had clear DA criteria due to syndromes and severe congenital anomalies and were candidates for elective eye surgery. Duration of the operation was 30 to 60 minutes. In all 30 cases, LMA placement with the classic method was not successful after 2 attempts by an expert. LMA was successfully inserted for all cases by the same person using the innovated method after meeting the required criteria (BIS=35-40). All ventilation indices were met and the operation was performed successfully with no complication. Conclusion: There is always a risk of unsuccessful LMA placement in difficult pediatric airways using the classic method of insertion. The innovated method recommends pushing down the tongue by the index finger of the left hand. Considering the hypersensitivity of children to hypoxia and risk of unsuccessful LMA placement by the classic method, the innovated placement method is advised in children suffering from anomalies associated with macroglossia. (Tanaffos2011; 10(2): 56-68)
Difficult pediatric airway,LMA,Sevoflurane,Muscle relaxant,Hypoxia
https://www.tanaffosjournal.ir/article_241125.html
https://www.tanaffosjournal.ir/article_241125_b369d68538e73937c5b0b7e12e46c762.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
Left Atrial Extension of Lung Carcinoma Simulating Myocardial Infarction, Unusual Presentation: Case Report and Literature Review
69
71
EN
Pradipta
Guha
Department of Cardiology, G.B.Pant Hospital, New Delhi-India,
Partha
Sardar
Department of General Medicine, Lal Bahadur Shastri Hospital,
Khichripur, New Delhi-India,
Soura
Mookerjee
Department of Cardiology, Medical College, Kolkata, West Bengal-India.
Santanu
Guha
Department of Cardiology, Medical College, Kolkata, West Bengal-India.
Lung malignancy invading the left atrium is rarely seen. We present a patient with a fast growing symptomatic lung mass.<br /> Electrocardiogram showed persistent coving ST elevation with no biomarker change. Transthoracic echocardiography<br /> showed a large left atrial mass attached to the free walls and extended into its appendage. An apparent continuity with a<br /> large lung mass compressing left ventricular lateral wall was observed which was better evident in computed tomography of<br /> the chest. (Tanaffos2011; 10(2): 69-71)
Left atrial mass,ST elevation,Lung malignancy
https://www.tanaffosjournal.ir/article_242214.html
https://www.tanaffosjournal.ir/article_242214_e1491998b575ce016bd6f9e477b4a3db.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
A 54-Year-Old Woman with Chronic Cough and an Endobronchial Mass
72
74
EN
Mehrdad M.
Behnia
Medical College of Georgia, Augusta, Georgia-USA
Philip W.
Catalano
Medical College of Georgia, Augusta, Georgia-USA
We report a case of a 54-year old female who presented with chronic cough. Computerized tomography (CT) scan of the chest was not remarkable. She underwent empirical treatment for common causes of chronic cough for months to no avail, after which flexible bronchoscopy revealed right lower lobe endobronchial mucoepidermoid carcinoma. Surgical resection resulted in complete resolution of the cough. In patients with refractory cough who do not respond to conventional medical therapy, examination of endobronchial tree by bronchoscopy is strongly recommended. (Tanaffos2011; 10(2): 72-74)
Mucoepidermoid carcinoma,Chronic cough,Bronchoscopy
https://www.tanaffosjournal.ir/article_242215.html
https://www.tanaffosjournal.ir/article_242215_e2eca9055714e39d61c0ab60f7331f73.pdf
National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
TANAFFOS (Respiration)
1735-0344
2345-3729
10
2(spiring)
2011
06
01
A 46-Year-Old Man with Fever and Numbness of Limbs
75
78
EN
Ilad Alavi
Darazam
Department of Internal Medicine, Division of Infectious Disease and Clinical Immunology,
Shirin
Karimi
Mycobacteriology Research Center,
Mehrdad
Bakhshayesh Karam
Pediatric Respiratory Disease Research Center,
Seyed Davood
Mansouri
Department of Internal Medicine, Division of Infectious Disease and Clinical Immunology,
https://www.tanaffosjournal.ir/article_242216.html
https://www.tanaffosjournal.ir/article_242216_dcf78eb38feb4976e61594325de6d0e1.pdf