@article { author = {Babamahmoodi, Abdolreza and Moniri, Afshin and Sadr, Makan and Poorhosseini, Seyed Mohammad and Rezaei, Mitra and Marjani, Majid and Velayati, Ali Akbar}, title = {Trisomy 21 as a Risk Factor for Severe Illness in COVID-19: Report of two Cases}, journal = {TANAFFOS (Respiration)}, volume = {19}, number = {4}, pages = {413-417}, year = {2020}, publisher = {National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran}, issn = {1735-0344}, eissn = {2345-3729}, doi = {}, abstract = {COVID-19 leads to mild symptoms within the majority of infected patients, but can cause severe multiple organ failure and death. There is only limited information regarding the consequences of this new emerging infection with congenital disorders.  According to the previous studies, many people with Down syndrome are considered high risk for complications related to respiratory diseases. We report two trisomy 21 patients who suffered from COVID-19 and summarize the early experience with COVID-19 and Down syndrome. The course of the disease was severe in these two cases, and our concern is close monitoring of the patients with Down syndrome for early signs of COVID-19.}, keywords = {Down Syndrome,COVID-19,Risk Factors,Trisomy, Risk factor}, url = {https://www.tanaffosjournal.ir/article_243459.html}, eprint = {https://www.tanaffosjournal.ir/article_243459_ad38f33dae1930fa2eebaf16fd3d52e8.pdf} }