@article { author = {Mirzaei, Alireza and Joharimoghadam, Mohamad Mehdi and Zabihiyeganeh, Mozhdeh}, title = {Adalimumab-Responsive Refractory Sarcoidosis Following Multiple Eyebrow Tattoos: A Case Report}, journal = {TANAFFOS (Respiration)}, volume = {16}, number = {1}, pages = {80-83}, year = {2017}, publisher = {National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran}, issn = {1735-0344}, eissn = {2345-3729}, doi = {}, abstract = {Sarcoidosis is a granulomatous disease that can involve multiple organs including the lungs, eyes, nerves, and skin. Cosmetic tattooing can be a predisposing factor for sarcoidosis, and its incidence is likely to increase along with its popularity. A 47-year-old woman with symptoms of fever and polyarthritis along with erythema nodosum lesions on the legs, swollen eyebrows, and a history of multiple eyebrow tattooing was referred to our center. Since the signs and symptoms were positive for Löfgren’s syndrome triad including erythema nodosum, bilateral hilar lymphadenopathy, and polyarthritis, a diagnosis of acute sarcoidosis was made, and treatment was started accordingly. The patient was unresponsive to routine therapeutic agents used for sarcoidosis; however, she successfully responded to adalimumab. Our case indicates that systemic sarcoidosis could develop as a reaction to cosmetic tattooing, which might be refractory to conventional therapeutic agents including corticosteroids and non-biologic disease-modifying antirheumatic drugs, while tumor necrosis factor antagonists such as adalimumab, could lead to disease remission.}, keywords = {Refractory sarcoidosis,Eyebrow,Adalimumab}, url = {https://www.tanaffosjournal.ir/article_242184.html}, eprint = {https://www.tanaffosjournal.ir/article_242184_b87b3e64b1e9397f7e82663b4d1512ac.pdf} }