@article { author = {Baniasadi, Shadi and Baradaran Shokouhi, Shokoufeh and Tabarsi, Payam and Alehashem, Maryam and Khalili, Hossein and Fahimi, Fanak and Alireza Nadji, Seyed}, title = {Prevalence of HLA-B*5701 and Its Relationship with Abacavir Hypersensitivity Reaction in Iranian HIV- Infected Patients}, journal = {TANAFFOS (Respiration)}, volume = {15}, number = {1}, pages = {48-52}, year = {2016}, publisher = {National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran}, issn = {1735-0344}, eissn = {2345-3729}, doi = {}, abstract = {Background: Hypersensitivity reaction (HSR) is a major adverse effect of abacavir (ABC), which occurs in 5-8% of Caucasians. The relationship between Human Leukocyte Antigen (HLA) and ABC HSR has been reported in various populations. It has been proposed to administer ABC only to HLA-B*5701 negative patients to avoid this reaction. The purpose of this study was to assess the prevalence of HLA-B*5701 in Iranian HIV positive patients. We also sought to find the relationship between this allele with ABC HSR in patients who received the medication. Materials and Methods: We screened patients for HLA-B*5701 allele using SybrGreen real time PCR-melting method on blood samples from HIV positive patients who were referred to our hospital. The quality of the extracted genome was evaluated by B-globin housekeeping gene as internal control prior to HLAB*5701 allele screening. Results: Of 198 HIV-infected patients, 6 (3.0%) had the HLA-B*5701 allele (95% CI, 1%–5%). Among the 28 patients who were given ABC, one individual had the HLA-B*5701 allele and experienced ABC HSR. Conclusion: Prevalence of HLA-B*5701 in Iranian patients was lower than that in Caucasians but was comparable with that of other Middle Eastern populations. Screening for HLA-B*5701 before ABC administration as part of antiretroviral therapy may reduce the risk of HSR.  }, keywords = {Abacavir,Antiretroviral therapy,HIV,HLA-B*5701 allele,Hypersensitivity reaction,Iran}, url = {https://www.tanaffosjournal.ir/article_240241.html}, eprint = {https://www.tanaffosjournal.ir/article_240241_7b71b2829b03cb8a3a1fe70dfb885f38.pdf} }